2025年5月27日 周二
Home > Archive>Volume 30, Issue 8, 2022 >661-668. DOI:10.20039/j.cnki.1007-3949.2022.08.003
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Research progress of sphingolipids in atherosclerosis
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1.Guangxi Key Laboratory of Basic Research in Sphingolipid Metabolism Related Diseases, the Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China;2.China-USA Lipids in Health and Disease Research Center, Guilin Medical University, Guilin, Guangxi 541001, China;3.Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, the Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China;4.Laboratory of Hepatobiliary and Pancreatic Surgery, the Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China;5.Department of General Surgery, Shenzhen Yantian District People's Hospital, Shenzhen, Guangdong 518081, China)

Clc Number:

R5

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    Abstract:

    Atherosclerosis is the main cause of most cardiovascular diseases, but its pathogenesis is complicated and has not been fully understood. More and more studies have shown that the disorder of lipid metabolism may play an important role in the initiation and development of atherosclerosis. As a group of bioactive lipids participating in cell structure component and signal transduction, sphingolipids have been proved to be abnormal in blood and vascular lesion in patients with cardiovascular diseases. Some sphingolipids may be potential biomarkers and therapeutic targets in cardiovascular diseases. This review is focused on the influences and regulatory mechanisms of sphingolipids on the initiation and development of atherosclerosis trying to find new ideas and molecular targets for the prevention and treatment of atherosclerosis.

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LIAO Sicong, QIU Zhidong, JIN Junfei. Research progress of sphingolipids in atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(8):661-668.

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History
  • Received:December 03,2021
  • Revised:January 18,2022
  • Online: July 11,2022
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