2025年6月11日 周三
Home > Archive>Volume 30, Issue 7, 2022 >568-574. DOI:10.20039/j.cnki.1007-3949.2022.07.003
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Targeting histamine/HR signal in HDC-expressing neutrophils to prevent thrombosis
Author:
Affiliation:

1.Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai 200032, China;2.Center of Cardiovascular Medicine, the Third People's Hospital of Huizhou, Huizhou, Guangdong 516003, China)

Clc Number:

R5

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    Abstract:

    Thrombosis and its complications are a clinical condition that endangers health. Neutrophil extracellular trap networks (NET) are extracellular fibrous networks formed by neutrophil-released, depolymerized chromatin that influence disease regression by activating platelets, accelerating clotting and thus promoting thrombosis. Histidine decarboxylase (HDC), a key enzyme catalyzing histamine production, is highly expressed in neutrophils, particular in the bone marrow-derived immature myeloid cells. Histamine signaling is involved in allergic reactions, gastric acid secretion, inflammation, immune responses, and tumorigenesis in relation to a variety of physiological and pathophysiological events. Targeting HDC-expressing neutrophils and the regulation of histamine related downstream signal on neutrophil differentiation, NET formation and thrombogenesis development might become a new antithrombotic strategy. This article mainly reviews the role of HDC-expression neutrophils inthrombosis.

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YANG Xiyang, XIAO Chun, YANG Xiangdong. Targeting histamine/HR signal in HDC-expressing neutrophils to prevent thrombosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(7):568-574.

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History
  • Received:December 24,2021
  • Revised:February 09,2022
  • Online: July 11,2022
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