Research progress of animal models of aortic aneurysm

doi:10.20039/j.cnki.1007-3949.2022.07.002

Home > Archive>Volume 30, Issue 7, 2022 >560-567. DOI:10.20039/j.cnki.1007-3949.2022.07.002

Research progress of animal models of aortic aneurysm
DOI:
                        10.20039/j.cnki.1007-3949.2022.07.002
                    
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                        WU Xianxian1,2WU Xianxian
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College & Key Laboratory of Human Disease Comparative Medicine, National Health Commission, Beijing 100021, China;Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021, China
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LIU Xing1,2LIU Xing
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College & Key Laboratory of Human Disease Comparative Medicine, National Health Commission, Beijing 100021, China;Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021, China
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YANG Zhiwei1,2YANG Zhiwei
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College & Key Laboratory of Human Disease Comparative Medicine, National Health Commission, Beijing 100021, China;Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021, China
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Affiliation:1.Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College & Key Laboratory of Human Disease Comparative Medicine, National Health Commission, Beijing 100021, China;2.Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021, China)
Clc Number:R331;R5
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Abstract:

Aortic aneurysm (AA) is a pathological dilatation disease of the aorta that is affected by multiple factors and has a potential risk of rupture. AA can be divided into thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) based on the location of aneurysm. The occurrence of TAA is highly relevant to genetic factors, and shows no age and gender differences. In contrast, the occurrence of AAA is related to age, gender, and atherosclerosis, but is not related with genetic factors. Most AA patients are asymptomatic, and generally have the characteristics of insidious onset and rupture to death. Therefore, AA is a serious life-threatening chronic disease, but its pathogenesis is not fully understood. The animal model of AA is of great significance to investigate the underlying pathophysiological mechanism, to develop and evaluate therapeutic drugs. Currently, there are many well-established animal models of AAA, but less of TAA. In fact, many established methods to induce AAA can also induce TAA. This review describes the AA animal models classified into non-dissected AA animal model and dissected AA animal model, and discusses the development methods and phenotypes of them, which may help us to find more efficient and reliable solutions against human aortic aneurysm.

Key words:aortic aneurysm; animal model; non-dissected AA animal model; dissected AA animal model

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WU Xianxian, LIU Xing, YANG Zhiwei. Research progress of animal models of aortic aneurysm[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(7):560-567.

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Received:September 15,2021
Revised:December 01,2021
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Online: July 11,2022
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