Cardiovascular disease (CVD) has the characteristics of high incidence, high disability and high fatality rate around the world, and vascular calcification (VC) is the main common pathological change which leading to the occurrence of CVD risk events, indicating VC is a potential target for prevention and treatment of CVD, but in view of the complex pathogenesis of VC, there is currently no effective means of treating VC. Iron is an essential trace element for human body, studies have found that iron homeostasis (IH) abnormality caused by iron overload or iron deficiency is involved in the occurrence and development of VC in different types of CVD and different stages of disease. Therefore, clarifying the abnormal mechanism of IH in VC will contribute to pointing out new directions for basic research and clinical therapy of VC.