Role of microRNA in regulating matrix metalloproteinase-2 and matrix metalloproteinase-9 in aortic aneurysm

Home > Archive>Volume 30, Issue 6, 2022 >529-534

Role of microRNA in regulating matrix metalloproteinase-2 and matrix metalloproteinase-9 in aortic aneurysm
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                        XU Haiqiang1XU Haiqiang
Department of Pathophysiology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China
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ZONG Yuan1ZONG Yuan
Department of Pathophysiology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China
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WAN Hengquan1WAN Hengquan
Department of Pathophysiology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China
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ZHAO Simin1ZHAO Simin
Department of Pathophysiology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China
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WANG Zuo1WANG Zuo
Department of Pathophysiology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China
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WANG Guixue2WANG Guixue
Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400030, China
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QU Shunlin1QU Shunlin
Department of Pathophysiology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China
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LI Guohua1,2LI Guohua
Department of Pathophysiology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China;Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400030, China
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Affiliation:1.Department of Pathophysiology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China;2.Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400030, China)
Clc Number:R5
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Abstract:

Aortic aneurysm (AA) is a cardiovascular disease with high morbidity and mortality. Its pathogenesis is extremely complex. Studies have confirmed that microRNA (miRNA) can regulate numerous pathophysiological processes, including inflammation, extracellular matrix (ECM) remodeling, and vascular smooth muscle cell (VSMC) proliferation and death, in AA. Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are important members of the MMP family, which also play an important role in the pathological process of AA. In recent years, it has been found that a variety of miRNA can directly or indirectly regulate the expression and activity of MMP-2 and MMP-9 in AA, thus affecting the occurrence and development of AA. This paper mainly summarizes the regulatory mechanisms of miRNA on MMP-2, MMP-9 and their roles in the occurrence and development of AA, so as to provide new ideas for the diagnosis and treatment of AA.

Key words:aortic aneurysm; microRNA; matrix metalloproteinase-2; matrix metalloproteinase-9

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XU Haiqiang, ZONG Yuan, WAN Hengquan, ZHAO Simin, WANG Zuo, WANG Guixue, QU Shunlin, LI Guohua. Role of microRNA in regulating matrix metalloproteinase-2 and matrix metalloproteinase-9 in aortic aneurysm[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(6):529-534.

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Received:January 17,2022
Revised:March 25,2022
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Online: May 10,2022
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