Research progress of cell pyroptosis in myocardial ischemia-reperfusion injury

Home > Archive>Volume 30, Issue 6, 2022 >524-528

Research progress of cell pyroptosis in myocardial ischemia-reperfusion injury
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                        ZHOU GangZHOU Gang
Institute of Cardiovascular Disease, Three Gorges University & Department of Cardiology, Yichang Central Peoples Hospital & Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, Hubei 443003, China
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WU HuiWU Hui
Institute of Cardiovascular Disease, Three Gorges University & Department of Cardiology, Yichang Central Peoples Hospital & Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, Hubei 443003, China
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LIU DiLIU Di
Institute of Cardiovascular Disease, Three Gorges University & Department of Cardiology, Yichang Central Peoples Hospital & Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, Hubei 443003, China
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LI YunzhaoLI Yunzhao
Institute of Cardiovascular Disease, Three Gorges University & Department of Cardiology, Yichang Central Peoples Hospital & Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, Hubei 443003, China
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ZHANG DongZHANG Dong
Institute of Cardiovascular Disease, Three Gorges University & Department of Cardiology, Yichang Central Peoples Hospital & Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, Hubei 443003, China
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Affiliation:Institute of Cardiovascular Disease, Three Gorges University & Department of Cardiology, Yichang Central People's Hospital & Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, Hubei 443003, China)
Clc Number:R541
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Abstract:

Myocardial ischemia-reperfusion injury (MIRI) is one of the main causes of high mortality in patients with myocardial infarction after active revascularization. It is of great significance to find effective intervention targets to alleviate MIRI and explore its protective mechanism. Cell pyroptosis is a form of inflammatory programmed cell death in addition to cell necrosis and apoptosis. In recent years, studies have found that pyroptosis is closely related to the occurrence and development of MIRI. This article reviews the pyroptosis and its mechanism of action in MIRI, and discusses the new research progress of small-molecule drugs, natural drugs and commonly used clinical drugs which affect cell pyroptosis and applied in the prevention and treatment of MIRI.

Key words:cell pyroptosis; myocardial ischemia-reperfusion injury; Nod-like receptor protein 3; cysteine aspartate specific proteinase 1

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ZHOU Gang, WU Hui, LIU Di, LI Yunzhao, ZHANG Dong. Research progress of cell pyroptosis in myocardial ischemia-reperfusion injury[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(6):524-528.

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Received:February 21,2021
Revised:April 23,2021
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Online: May 10,2022
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