Mechanism and clinical study of Danshen-Chuanxiong herbal pair in the treatment of cardiovascular and cerebrovascular diseases

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Mechanism and clinical study of Danshen-Chuanxiong herbal pair in the treatment of cardiovascular and cerebrovascular diseases
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                        ZHAO Yuhan1,2ZHAO Yuhan
State Key Laboratory of Component Traditional Chinese Medicine Jointly Established by the Province and the Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Joint Research Institute, Tianjin 300457, China
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XIAO Guangxu1,2XIAO Guangxu
State Key Laboratory of Component Traditional Chinese Medicine Jointly Established by the Province and the Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Joint Research Institute, Tianjin 300457, China
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FAN Siwen1,2FAN Siwen
State Key Laboratory of Component Traditional Chinese Medicine Jointly Established by the Province and the Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Joint Research Institute, Tianjin 300457, China
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WANG Xiaoying3WANG Xiaoying
Department of Neurosurgery, Center for Clinical Neuroscience Research, Tulane University School of Medicine, New York 70118, USA
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ZHU Yan1,2ZHU Yan
State Key Laboratory of Component Traditional Chinese Medicine Jointly Established by the Province and the Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Joint Research Institute, Tianjin 300457, China
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Affiliation:1.State Key Laboratory of Component Traditional Chinese Medicine Jointly Established by the Province and the Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Joint Research Institute, Tianjin 300457, China;3.Department of Neurosurgery, Center for Clinical Neuroscience Research, Tulane University School of Medicine, New York 70118, USA)
Clc Number:R966；R5
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Abstract:

Drug compatibility is the key guiding ideology of traditional Chinese medicine compound prescriptions, and it is also an important content of the modernization research of traditional Chinese medicine. Danshen and Chuanxiong are widely used in traditional Chinese medicine clinic to prevent and treat cardiovascular and cerebrovascular diseases, such as coronary heart disease, angina pectoris, stroke and atherosclerosis, etc. Recent studies have found that Danshen-Chuanxiong herbal pair is the most common combination in traditional Chinese medicine for blood-activating and stasis-removing, which can exert pharmacological effects such as anti-atherosclerosis, alleviation of vascular endothelial injury, anti-inflammatory response, anti-ischemia/reperfusion injury, and anti-thrombosis. This paper systematically expounds the research on Danshen-Chuanxiong herbal pair from the aspects of material basis, mechanism of action, and clinical application, and provides a basis for the rational application and effective development of modern Chinese medicine based on the Danshen-Chuanxiong herbal pair.

Key words:Danshen-Chuanxiong herbal pair; compatibility; cardiovascular and cerebrovascular diseases; blood-activating and stasis-removing

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ZHAO Yuhan, XIAO Guangxu, FAN Siwen, WANG Xiaoying, ZHU Yan. Mechanism and clinical study of Danshen-Chuanxiong herbal pair in the treatment of cardiovascular and cerebrovascular diseases[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(6):461-469.

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Received:September 29,2021
Revised:November 06,2021
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Online: May 10,2022
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