Progress in the regulation of macrophage phenotype in atherosclerosis

Home > Archive>Volume 30, Issue 4, 2022 >364-368

Progress in the regulation of macrophage phenotype in atherosclerosis
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                        SHI Mingxi1SHI Mingxi
Department of Physiology/The Neuroscience Institute, Hengyang Medical School, University of South China & Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, Hengyang, Hunan 421001, China
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JIANG Liping1,2JIANG Liping
Department of Physiology/The Neuroscience Institute, Hengyang Medical School, University of South China & Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, Hengyang, Hunan 421001, China;Hunan Taihe Hospital, Changsha, Hunan 410004, China
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CHEN Jinzhi1CHEN Jinzhi
Department of Physiology/The Neuroscience Institute, Hengyang Medical School, University of South China & Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, Hengyang, Hunan 421001, China
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HE Pingping3HE Pingping
School of Nursing, University of South China, Hengyang, Hunan 421001, China
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JIANG Weiwei1JIANG Weiwei
Department of Physiology/The Neuroscience Institute, Hengyang Medical School, University of South China & Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, Hengyang, Hunan 421001, China
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ZHANG Xingting1ZHANG Xingting
Department of Physiology/The Neuroscience Institute, Hengyang Medical School, University of South China & Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, Hengyang, Hunan 421001, China
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WANG Gang4WANG Gang
Department of Cardiology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China
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YIN Shanhui5YIN Shanhui
Department of Neonatology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China
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OU YANG Xinping1OU YANG Xinping
Department of Physiology/The Neuroscience Institute, Hengyang Medical School, University of South China & Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, Hengyang, Hunan 421001, China
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Affiliation:1.Department of Physiology/The Neuroscience Institute, Hengyang Medical School, University of South China & Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, Hengyang, Hunan 421001, China;2.Hunan Taihe Hospital, Changsha, Hunan 410004, China;3.School of Nursing, University of South China, Hengyang, Hunan 421001, China;4.Department of Cardiology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China;5.Department of Neonatology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China)
Clc Number:R34;R5
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Abstract:

Macrophages are a type of phagocytes, which play a crucial role in the occurrence and development of atherosclerosis. Studies have shown that different phenotypes of macrophages play different roles in the progression of atherosclerosis. Reducing the local proliferation of pro-inflammatory macrophages and inducing macrophages to transform into an anti-inflammatory phenotype are crucial to the treatmenent of atherosclerosis in the future. This article reviews the macrophage phenotype, phenotypic regulation related signaling pathways, and therapeutic strategies targeting the regulation of macrophage phenotypes, hoping to provide new targets or avenues for the prevention and treatment of atherosclerosis.

Key words:macrophages; atherosclerosis; macrophage phenotype; phenotypic transformation; macrophage heterogeneity

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SHI Mingxi, JIANG Liping, CHEN Jinzhi, HE Pingping, JIANG Weiwei, ZHANG Xingting, WANG Gang, YIN Shanhui, OU YANG Xinping. Progress in the regulation of macrophage phenotype in atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(4):364-368.

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Received:March 10,2021
Revised:November 24,2021
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Online: March 31,2022
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