Research progress of KLF15 in cardiovascular disease

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Research progress of KLF15 in cardiovascular disease
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                        MAO ShuaiMAO Shuai
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China & Cardiovascular Research Institute, Wuhan University, Wuhan, Hubei 430060, China & Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China
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WU GangWU Gang
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China & Cardiovascular Research Institute, Wuhan University, Wuhan, Hubei 430060, China & Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China
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Affiliation:Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China & Cardiovascular Research Institute, Wuhan University, Wuhan, Hubei 430060, China & Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China)
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Abstract:

Krüppel-like factor 15 (KLF15) is a critical member of Krüppel-like factor (KLF) family containing zinc finger. Studies have shown that KLF15 plays an important role in regulating various signal transduction pathways and energy metabolism. KLF15 can play an anti-myocardial remodeling role by affecting myocyte enhancer factor 2 (MEF2), transforming growth factor β (TGF-β) and so on. In addition, KLF15 is the key factor to maintain ventricular arrhythmia and circadian rhythm. This paper reviews the physiological and pathological role of KLF15 in the heart and the latest research progress in cardiovascular diseases.

Key words:Krüppel-like factor 15; energy metabolism; cardiovascular disease

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MAO Shuai, WU Gang. Research progress of KLF15 in cardiovascular disease[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(4):352-356.

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Received:June 16,2021
Revised:October 12,2021
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Online: March 31,2022
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