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Heparanase and atherosclerosis
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Affiliation:

1.Graduate School, Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia 014040, China;2.Department of Cardiology, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia 014040, China)

Clc Number:

R543

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    Abstract:

    Atherosclerosis is a common cardiovascular disease with high mortality. Heparanase is an endogenous β-D-glucuronidase that can cleave the upper side chain of acetylproteoglycan sulfate in the outer membrane of the cell. And its non-enzymatic activity also plays a role in many normal physiological activities or pathological diseases. Studies have shown that heparanase is closely related to the formation and progression of atherosclerosis. This paper reviews the effects of heparanase on endothelial injury, coagulation, inflammatory factors and lipid accumulation, and expounds its role and mechanism in the occurrence and development of atherosclerosis.

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LIU Ruihong, WANG Mengqin, HAN Xuanmao. Heparanase and atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(3):255-259.

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History
  • Received:May 14,2020
  • Revised:October 30,2021
  • Online: January 14,2022
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