With the changes of living standard and lifestyle, metabolic cardiovascular diseases characterized by obesity are increasing by years. The disorder of adipose function and adipocytokines, because of adipose tissue’s pathological expansion induced by obesity, participates in the whole process of the occurrence and development of cardiovascular disease. This article reviews different types of adipose tissue involve in maintenance of cardiovascular homeostasis or regulation of cardiovascular disease by endocrine or paracrine effects under physiological or pathological conditions. Therefore, it provides new ideas and new targets for the precise treatment of obesity-related metabolic cardiovascular diseases.