Research progress of miR-206 and cardiovascular disease
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1.The Cardiovascular Medicine Department of First Clinical Medical College, Shanxi Medical University;2.Key laboratory of Cellular Physiology of Shanxi Medical University, Ministry of Education;3.The Cardiovascular Medicine Department of the First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China)

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    Abstract:

    MicroRNAs (miRNAs), a large class of short non-coding RNAs, can directly bind to the 3′ untranslated region of target genes, thus affecting gene expression and playing a key role in cardiovascular diseases. Among them, miRNA-206 (miR-206) is a key regulator of heart development and physiological activities, and can not only be used as a marker molecule for diagnosis, but also as a targeted action point for disease treatment. This paper reviews the basic functions of miR-206 in regulating cardiomyocytes, endothelial cells, smooth muscle cells, autonomic nerve cells and other cells, as well as the specific roles and mechanisms of miR-206 in the occurrence and development of coronary artery disease, myocardial infarction, heart failure, arrhythmia, pulmonary hypertension and other diseases.

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WANG Haoyue, TIAN Jing, HAN Qinghua. Research progress of miR-206 and cardiovascular disease[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2021,29(11):1007-1012.

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History
  • Received:January 08,2021
  • Revised:July 07,2021
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  • Online: November 18,2021
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