Research progress on the relationship between proprotein convertase subtilisin/kexin type 9 and myocardial infarction
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1.The First Clinical Medicine School of Lanzhou University, Lanzhou, Gansu 730000;2.The Heart Center of the First Hospital of Lanzhou University, Lanzhou, Gansu 730000;3.The Key Laboratory of Cardiovascular Diseases of Gansu Province, Lanzhou, Gansu 730000)

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R5

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    Abstract:

    Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proteinase K subfamily of the proprotein convertase family, which can combine with low-density lipoprotein receptor (LDLR), and inhibit the repeated use of LDLR, resulting in a decrease in LDLR on the surface of liver cells, an increase in LDL levels in peripheral blood and a series of pathophysiological processes such as abnormal blood lipid metabolism. Current studies have shown that PCSK9 has a certain correlation with myocardial infarction, and may regulate the occurrence and development of myocardial infarction through a way independent of low-density lipoprotein cholesterol (LDLC). This article will review the research progress of PCSK9 and myocardial infarction.

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XU Jin, PENG Yu, ZHANG Zheng. Research progress on the relationship between proprotein convertase subtilisin/kexin type 9 and myocardial infarction[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2021,29(11):1000-1006.

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History
  • Received:January 09,2021
  • Revised:July 06,2021
  • Adopted:
  • Online: November 18,2021
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