Research progress of vascular peroxidase 1 mediated oxidative stress in cardiovascular diseases

Home > Archive>Volume 29, Issue 11, 2021 >927-933, 954

Research progress of vascular peroxidase 1 mediated oxidative stress in cardiovascular diseases
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                        FU Minyi1,2,3FU Minyi
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;Institute of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;National Clinical Research Center for Geriatric Disorders Xiangya, Changsha, Hunan 410008, China
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LUO Fangmei4LUO Fangmei
Department of Pharmacy, Hunan Children’s Hospital, Changsha, Hunan 410007, China
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LIU Bin1,2,3LIU Bin
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;Institute of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;National Clinical Research Center for Geriatric Disorders Xiangya, Changsha, Hunan 410008, China
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Affiliation:1.Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;2.Institute of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;3.National Clinical Research Center for Geriatric Disorders (Xiangya), Changsha, Hunan 410008, China;4.Department of Pharmacy, Hunan Children’s Hospital, Changsha, Hunan 410007, China)
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Abstract:

As a recently identified family member of the heme-containing peroxidases in cardiovascular system, vascular peroxidase 1 (VPO1) can utilize NADPH oxidase (NOX)-derived hydrogen peroxide (H₂O₂) to produce hypochlorous acid (HClO) then greatly amplify the oxidatice stress, and it is implicated in the pathogenesis of several cardiovascular diseases such as hypertension, atherosclerosis, myocardial infarction and pulmonary arterial hypertension. This review aims to summarize the role and potential mechanism of VPO1-mediated oxidative stress in cardiovascular diseases.

Key words:vascular peroxidase 1; oxidative stress; cardiovascular diseases; hydrogen peroxide; hypochlorous acid

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FU Minyi, LUO Fangmei, LIU Bin. Research progress of vascular peroxidase 1 mediated oxidative stress in cardiovascular diseases[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2021,29(11):927-933, 954.

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Received:June 09,2021
Revised:July 06,2021
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Online: November 18,2021
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