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The structural characteristics of secreted frizzled related protein 4 and its effect on lipid metabolism
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1.Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, Shaanxi 710021, China;2.Department of Anesthesiology, Air Force Medical University Stomatological Hospital, Xi'an, Shaanxi 710032, China;3.Department of Histology and Embryology, Xi'an Medical University, Xi'an, Shaanxi 710021, China)

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R5;R3

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    Abstract:

    Secreted frizzled related protein 4 (SFRP4) is an antagonistic inhibitor of Wnt signaling and plays an important role in human development. Abnormal gene expression and protein secretion of SFRP4 result in the pathological changes. This review introduced the structural characteristics, tissue distribution and expression pattern of SFRP4 during embryonic development. As an inhibitor of Wnts signaling, SFRP4 plays a key role in regulating adipogenesis. In clinic, the level of SFRP4 protein in the serum of diabetic patients was abnormally increased, which was negatively correlated with insulin secretion, indicating that SFRP4 plays an important role in the process of glucose metabolism and insulin resistance. In recent years, SFRP4 has attracted extensive attention in the research of obesity and lipid metabolism. Systematic research on SFRP4 can not only provide information related to diseases, but also serve as a novel drug and treatment target.

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GUAN Hua, ZHENG Huiyuan, WANG Lan, YU Qi, XU Lixian, XU Cangbao. The structural characteristics of secreted frizzled related protein 4 and its effect on lipid metabolism[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2021,29(10):903-907.

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History
  • Received:June 02,2020
  • Revised:March 23,2021
  • Online: October 13,2021
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