Aim To investigate the clinical manifestations, pathological and imaging features of eosinophilic granulomatosis with polyangiitis (EGPA) in order to improve the level of clinical diagnosis and treatment. Methods The clinical data of 13 patients with EGPA diagnosed in General Hospital of Chinese People's Liberation Army from January 2006 to April 2021 were analyzed retrospectively, including basic information, clinical manifestations, conditions of involved organs, hematology and imaging examinations, pathological examinations and treatments, and follow-up happening.Results Among the 13 patients with EGPA, 7 were males and 6 were females; aged from 27 to 60 years old, with a median age of 37 years. The involved organs include respiratory system, nervous system, digestive system, cardiovascular system, urinary system, skin, ear, nose, throat, eyes, and etc. Leukocytosis was found in 10 patients, and eosinophils (Eos) increasing was found in 11 patients. Elevated IgE was found in 10 patients. 6 cases were positive for antineutrophil cytoplasmic autoantibody. 10 cases of pathological examination showed obvious Eos infiltration. All patients were treated with hormone and immunosuppressant. 13 cases were followed up, 4 cases recurred and 1 case died. Conclusions The main clinical features of EGPA are increased Eos in peripheral blood and Eos infiltration in pathological tissues, involving multiple systems, especially the respiratory system. Pathological biopsy is helpful for diagnosis. Hormone and immunosuppressant are effective in the treatment of EGPA.