Research progress of the relationship between S100A8 and S100A9 and coronary heart disease

Home > Archive>Volume 29, Issue 7, 2021 >641-644

Research progress of the relationship between S100A8 and S100A9 and coronary heart disease
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                        WANG Runqing1,2WANG Runqing
Department of Cardiology, First Affiliated Hospital of Lanzhou University, Lanzhou Gansu730000, China;Key Laboratory of Cardiovascular Disease, Lanzhou, Gansu 730000, China
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WANG Yongxiang2WANG Yongxiang
Key Laboratory of Cardiovascular Disease, Lanzhou, Gansu 730000, China
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ZHANG Zheng1,2ZHANG Zheng
Department of Cardiology, First Affiliated Hospital of Lanzhou University, Lanzhou Gansu730000, China;Key Laboratory of Cardiovascular Disease, Lanzhou, Gansu 730000, China
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Affiliation:1.Department of Cardiology, First Affiliated Hospital of Lanzhou University, Lanzhou Gansu730000, China;2.Key Laboratory of Cardiovascular Disease, Lanzhou, Gansu 730000, China)
Clc Number:R543
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Abstract:

S100A8 and S100A9, as endogenous risk-associated molecular patterns, recognize Toll-like receptor 4 and advanced glycation end product receptors, participate in immune response, change endothelial permeability and promote inflammation within the plaque, which affects the development of atherosclerosis. In addition, the elevated plasma levels of S100A8 and S100A9 are associated with an increased risk of future cardiovascular events. This article reviews the research status of S100A8 and S100A9 and their application prospects in the prevention, treatment and prognosis evaluation with coronary heart disease.

Key words:S100A8; S100A9; atherosclerosis; acute coronary syndrome

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WANG Runqing, WANG Yongxiang, ZHANG Zheng. Research progress of the relationship between S100A8 and S100A9 and coronary heart disease[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2021,29(7):641-644.

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Received:March 25,2020
Revised:November 17,2020
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Online: June 28,2021
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