Aim To evaluate the safety and effectiveness of percutaneous coronary intervention via distal transradial artery access. Methods Pubmed, Embase, Web of Science, Cochrane Library, China Biomedical Service System (Sinomed), China Knowledge Network (CNKI), Wanfang Data Knowledge Service Platform (Wanfang Data), VIP and other databases were searched by computer. The search time limit was from Janurary 2017 to May 2020. Two researchers conducted a Meta-analysis after analyzing and evaluating according to the Cochrance bias risk assessment tool.Results A total of 1 617 articles were obtained in various databases and other channels according to a predetermined search strategy, excluding unreasonable research design, no control group or control group as other parts of blood vessels (such as femoral artery, etc.), animal experiments, reviews, systematic reviews, and case reports were excluded. 10 articles were finally selected, Meta analysis results showed that there was no significant difference in the success rate of coronary puncture, the radial artery spasticity, and local hematoma (P＞0.05). However, the the radial artery occlusion was lower (OR＝0.4,5%CI(0.8,0.69),Z＝3.56,P＜0.05) in the distal radial artery path than in the traditional radial artery pathology. Conclusion Distal transradial artery access is safer and more effective than traditional radial artery access for coronary artery intervention. It can reduce radial artery occlusion and can be used as an alternative branch of the traditional route.