Research status and progress of carotid atherosclerotic intraplaque neovascularization
Author:
Affiliation:

1.Department of Vascular Surgery, the Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China;2.Peking University China-Japan Friendship School of Clinical Medical, Beijing 100029, China)

Clc Number:

R5;R654.3

  • Article
  • | |
  • Metrics
  • |
  • Reference [46]
  • | | | |
  • Comments
    Abstract:

    Rupture of carotid atherosclerotic plaque is one of the important causes of stroke. A large number of studies have confirmed that carotid plaque neovascularization is an important factor leading to intraplaque hemorrhage and rupture. Inflammatory factors and all kinds of cells enter the plaque through intraplaque neovascularization, which leads to the destruction of plaque stability. But the important related factors and main mechanisms affecting the formation of intraplaque neovascularization are not completely clear. Therefore, to identify intraplaque neovascularization and explore the related factors and mechanism of intraplaque neovascularization is the key to study plaque instability caused by intraplaque neovascularization. Inhibition of intraplaque neovascularization may be a new strategy for prevention and treatment of carotid plaque rupture and reduction of cerebral embolism. The purpose of this review is to explore the related factors, mechanism and the latest research progress of detection and imaging of carotid intraplaque neovascularization, so as to provide support for the diagnosis and treatment of clinical diseases.

    Reference
    [1] 陈竺.全国第三次死因回顾抽样调查报告.北京:中国协和医科大学出版社, 2008:10-17.
    [2] Meschia JF, Bushnell C, Boden-Albala B, et al.Guidelines for the primary prevention of stroke:a statement for healthcare professionals from the American Heart Association/American Stroke Association.Stroke, 4,5(12):3754-3832.
    [3] Pelisek J, Eckstein HH, Zernecke A.Pathophysiological mechanisms of carotid plaque vulnerability:impact on ischemic stroke.Arch Immunol Ther Exp (Warsz), 2,0(6):431-442.
    [4] 中华医学会外科学分会血管外科学组.颈动脉狭窄诊治指南.中华血管外科杂志, 7,2(2):78-79.
    [5] Howard DP, van Lammeren GW, Redgrave JN, et al.Histological features of carotid plaque in patients with ocular ischemia versus cerebral events.Stroke, 3,4(3):734-739.
    [6] Gorgui J, Gasbarrino K, Georgakis MK, et al.Circulating adiponectin levels in relation to carotid atherosclerotic plaque presence, ischemic stroke risk, and mortality:a systematic review and Meta-analyses.Metabolism, 7,9:51-66.
    [7] Abbott AL, Paraskevas KI, Kakkos SK, et al.Systematic review of guidelines for the management of asymptomatic and symptomatic carotid stenosis.Stroke, 5,6(11):3288-3301.
    [8] Brinjikji W, Huston IJ, Rabinstein AA, et al.Contemporary carotid imaging:from degree of stenosis to plaque vulnerability.J Neurosurg, 6,4(1):27-42.
    [9] Madden JA.Role of the vascular endothelium and plaque in acute ischemic stroke.Neurology, 2,9(13 Suppl 1):S58-S62.
    [10] Michel JB, Virmani R, Arbustini E, et al.Intraplaque haemorrhages as the trigger of plaque vulnerability.Eur Heart J, 1,2(16):1977-1985.
    [11] de Vries MR, Quax PH.Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization.Curr Opin Lipidol, 6,7(5):499-506.
    [12] Haasdijk RA, den Dekker WK, Cheng C, et al.THSD1 preserves vascular integrity and protects against intraplaque haemorrhaging in ApoE-/- mice.Cardiovasc Res, 6,0(1):129-139.
    [13] Folkman J.Angiogenesis in cancer, vascular, rheumatoid and other disease.Nat Med, 5,1(1):27-31.
    [14] Pandya NM, Dhalla NS, Santani DD.Angiogenesis--a new target for future therapy.Vascul Pharmacol, 6,4(5):265-274.
    [15] Paterson JC.Vascularization and hemorrhage of the intima of arteriosclerotic coronary arteries.Arch.Path, 6,3(1):313-324.
    [16] Shoeibi S, Mozdziak P, Mohammadi S.Important signals regulating coronary artery angiogenesis.Microvasc Res, 8,7:1-9.
    [17] Kazemi-Bajestani SM, Ghayour-Mobarhan M.Concept of atherosclerosis velocity:is it a better measure of cardiovascular risk.Iran J Med Sci, 3,8(3):210-220.
    [18] Lu J, Duan W, Qiao A.Finite element analysis of mechanics of neovessels with intraplaque hemorrhage in carotid atherosclerosis.Biomed Eng Online, 5,4(Suppl 1):S3.
    [19] Mofidi R, Rigden, B.Carotid plaque morphology:plaque instability and correllation with development of ischaemic neurological events.Carotid Artery Disease, 2014:85-104.
    [20] Potente M, Gerhardt H, Carmeliet P.Basic and therapeutic aspects of angiogenesis.Cell, 1,6(6):873-887.
    [21] Ogata A, Kawashima M, Wakamiya T, et al.Carotid artery stenosis with a high-intensity signal plaque on time-of-flight magnetic resonance angiography and association with evidence of intraplaque hypoxia.J Neurosurg, 7,6(6):1873-1878.
    [22] Chistiakov DA, Orekhov AN, Bobryshev YV.Contribution of neovascularization and intraplaque haemorrhage to atherosclerotic plaque progression and instability.Acta Physiol (Oxf), 5,3(3):539-553.
    [23] Basic J, Stojkovic S, Assadian A, et al.The relevance of vascular endothelial growth factor, hypoxia inducible factor-1 alpha, and clusterin in carotid plaque instability.J Stroke Cerebrovasc Dis, 9,8(6):1540-1545.
    [24] Simons M, Gordon E, Claesson-Welsh L.Mechanisms and regulation of endothelial VEGF receptor signalling.Nat Rev Mol Cell Biol, 6,7(10):611-625.
    [25] Pelisek J, Well G, Reeps C, et al.Neovascularization and angiogenic factors in advanced human carotid artery stenosis.Circ J, 2,6(5):1274-1282.
    [26] Stefanadis C, Toutouzas K, Stefanadi E, et al.Inhibition of plaque neovascularization and intimal hyperplasia by specific targeting vascular endothelial growth factor with bevacizumab-eluting stent:an experimental study.Atherosclerosis, 7,5(2):269-276.
    [27] Bieke van der Veken, Guido RM, Wim M.Axitinib attenuates intraplaque angiogenesis, haemorrhages and plaque destabilization in mice.Vascul Pharmacol, 8,0:34-40.
    [28] Koutouzis M, Nomikos A, Nikolidakis S, et al.Statin treated patients have reduced intraplaque angiogenesis in carotid endarterectomy specimens.Atherosclerosis, 7,2(2):457-463.
    [29] Bertolino P, Deckers M, Lebrin F, et al.Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders.Chest, 5,8(6 Suppl):585S-590S.
    [30] Nanda V, Downing KP, Ye J, et al.CDKN2B regulates TGFβ signaling and smooth muscle cell investment of hypoxic neovessels.Circ Res, 6,8(2):230-240.
    [31] Doyle B, Caplice N.Plaque neovascularization and antiangiogenic therapy for atherosclerosis.J Am Coll Cardiol, 7,9(21):2073-2080.
    [32] Mao Y, Liu X, Song Y, et al.VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not PDGF-BB/PDGFR-beta play important roles in promoting immature and inflammatory intraplaque angiogenesis.PLoS One, 8,3(8):e0201395.
    [33] Gonalves I, Den RH, Nahrendorf M, et al.Detecting the vulnerable plaque in patients.J Intern Med, 5,8(5):520-530.
    [34] Parma L, Baganha F, Quax PH, et al.Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis.Eur J Pharmacol, 7,6:107-115.
    [35] Bieke Van der Veken, Guido RM, Wim M.Intraplaque neovascularization as a novel therapeutic target in advanced atherosclerosis.Expert Opin Ther Targets, 6,0(10):1247-1257.
    [36] Kodama T, Narula N, Agozzino M, et al.Pathology of plaque haemorrhage and neovascularization of coronary artery.J Cardiovasc Med (Hagerstown), 2,3(10):620-627.
    [37] Taqueti VR, Di Carli MF, Jerosch-Herold M, et al.Increased microvascularization and vessel permeability associate with active inflammation in human atheromata.Circ Cardiovasc Imaging, 4,7(6):920-929.
    [38] Calcagno C, Mulder WJ, Nahrendorf M, et al.Systems biology and noninvasive imaging of atherosclerosis.Arterioscler Thromb Vasc Biol, 6,6(2):e1-e8.
    [39] Pérez-Medina C, Binderup T, Lobatto ME, et al.In vivo PET imaging of HDL in multiple atherosclerosis models.JACC Cardiovasc Imaging, 6,9(8):950-961.
    [40] Akkus Z, Van Burken G, van den Oord SC, et al.Carotid intraplaque neovascularization quantification software (CINQS).IEEE J Biomed Health Inform, 5,9(1):332-338.
    [41] Van Den Oord SC, Akkus Z, Renaud G, et al.Assessment of carotid atherosclerosis, intraplaque neovascularization, and plaque ulceration using quantitative contrast-enhanced ultrasound in asymptomatic patients with diabetes mellitus.Eur Heart J Cardiovasc Imaging, 4,5(11):1213-1218.
    [42] Matter CM, Schuler PK, Alessi P, et al.Molecular imaging of atherosclerotic plaques using a human antibody against the extra-domain B of fibronectin.Circ Res, 4,5(12):1225-1233.
    [43] Bourantas CV, Garcia-Garcia HM, Torii R, et al.Vulnerable plaque detection:an unrealistic quest or a feasible objective with a clinical value.Heart, 6,2(8):581-589.
    [44] Bourantas CV, Jaffer FA, Gijsen FJ, et al.Hybrid intravascular imaging:recent advances,technical considerations,and current applications in the study of plaque pathophysiology.Eur Heart J, 7,8(6):400-412.
    [45] Liu HY, Zhou J, Tong H, et al.Quantitative evaluation of atherosclerotic plaques and intraplaque neovascularization using contrast-enhanced ultrasound after treatment with atorvastatin in rabbits.Biomed Pharmacother, 7,2:277-284.
    [46] Kurdi A, Roth L, van der Veken B, et al.Everolimus depletes plaque macrophages, abolishes intraplaque neovascularization and improves survival in mice with advanced atherosclerosis.Vascul Pharmacol, 9,3:70-76.
    Related
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

QI Bingcai, JIN Qiwen, HU Jie, XING Miao, YUAN Meng, ZHANG Zhixin, DONG Honglin. Research status and progress of carotid atherosclerotic intraplaque neovascularization[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2021,29(4):359-362, 368.

Copy
Share
Article Metrics
  • Abstract:832
  • PDF: 1139
  • HTML: 0
  • Cited by: 0
History
  • Received:March 18,2020
  • Revised:May 09,2020
  • Online: April 14,2021
Article QR Code