Aim To investigate the effect and mechanism of fucosyltransferase 8 (Fut8) on the migration of foam cells. Methods The change of Fut8 expression was detected after the foam cell model was established, and the direct relationship between foam cell motility and Fut8 expression was identified. The effects of Fut8 overexpression on the fibrous actin (F-actin) polymerization and the phosphorylation of upstream molecule focal adhesion kinase (FAK) were examined. Results During the formation of foam cells, the expression of Fut8 was significantly down-regulated, and overexpression of Fut8 could repair the impaired migration of foam cells. Expression of F-actin was significantly down-regulated as foam cell motility decreased, and was regulated by Fut8. Phosphorylation of FAK was significantly inhibited when Fut8 expression was down-regulated, and overexpression of Fut8 could result in significantly enhanced phosphory-lation of FAK. Conclusion Inhibition of Fut8-FAK-F-actin pathway may be one of the reasons for the weakening of foam cell motility.