2025年6月10日 周二
Home > Archive>Volume 28, Issue 12, 2020 >1054-1059
PDF HTML XML Export Cite reminder
Association between high density lipoprotein particle size and silent myocardial ischemia in young patients with coronary heart disease
Author:
Affiliation:

1.Department of Cardiology, the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, China;2.Key Laboratory of Aging and Vascular Homeostasis of Sichuan Higher Education Institutes, Chengdu, Sichuan 610500, China)

Clc Number:

R5

  • Article
    • | |
  • Metrics
    • |
  • Reference [22]
    • | | | |
  • Comments
    Abstract:

    Aim To explore association between high density lipoprotein (HDL) particle size and silent myocardial ischemia (SMI) in young patients with coronary heart disease (CHD). Methods Blood samples were obtained on admission in 469 consecutive patients with CHD. Patients were divided into SMI group (n=194) and non-SMI group (n=275). General data of the patients were collected, and serum total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDLC), high density lipoprotein-cholesterol (HDLC), apolipoprotein A1(ApoA1) and related biochemical indexes were examined. Quantitative indicator of HDL particle size was measured by HDLC/ApoA1, and other lipid parameters (TC/HDLC, non-HDLC, TG/HDLC, LDLC/HDLC) were assessed. Logistic regression analysis was performed to define the independent predictors of SMI. Results Levels of TC, uric acid, LDLC, LDLC/HDLC, TC/HDLC, non-HDL were significantly lower in patients with SMI than those in patients with non-SMI (P＜0.05). Levels of HDLC, ApoA1, HDLC/ApoA1 were significantly higher in patients with SMI than those in patients with non-SMI (P＜0.05). Results of correlation analysis showed HDL particle size (HDLC/ApoA1) was negatively correlated with Gensini scores (r=－0.405,P＜0.05). Logistic regression analysis showed that HDL particle size (HDLC/ApoA1) was independent predictor of SMI in young patients with CHD. Receiver operating characteristic (ROC) curve analysis showed that the optimal cut-off point of HDL particle size (HDLC/ApoA1) in predicting SMI was 0.36, sensitivity was 92.1% and specificity was 75.5%. Conclusion HDL particle size (HDLC/ApoA1) have certain predictive value for SMI in young patients with CHD.

    Reference
    [1] Sanchis-Gomar F, Perez-Quilis C, Leischik R, et al.Epidemiology of coronary heart disease and acute coronary syndrome.Ann Transl Med, 6,4(13):256-268.
    [2] Knuuti J, Wijns W, Saraste A, et al.2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes.Eur Heart J, 9,1(3):407-477.
    [3] Doi S, Suzuki M, Funamizu T, et al.Clinical features of potential after-effects of percutaneous coronary intervention in the treatment of silent myocardial ischemia.Heart Vessels, 9,4(6):1917-1924.
    [4] Xi Z, Zhang HW, Zhang Y, et al.Impact of smoking status on lipoprotein subfractions:data from an untreated Chinese cohort.Biomed Environ Sci, 7,0(4):235-243.
    [5] Hunter WG, McGarrah RW, Kelly JP, et al.High-density lipoprotein particle subfractions in heart failure with preserved or reduced ejection fraction.J Am Coll Cardiol, 9,3(2):177-186.
    [6] Mazer NA, Giulianini F, Paynter NP, et al.A comparison of the theoretical relationship between HDL size and the ratio of HDL cholesterol to apolipoprotein AI with experimental results from the Women's Health Study.Clin Chem, 3,9(6):949-958.
    [7] Corder K, Sharp SJ, Atkin AJ, et al.Age-related patterns of vigorous-intensity physical activity in youth:the International Children's Accelerometry Database.Prev Med Rep, 6,4:17-22.
    [8] Wan J, Zhou P, Wang D, et al.Impact of normal weight central obesity on clinical outcomes in male patients with premature acute coronary syndrome.Angiology, 9,0(10):960-968.
    [9] Serrano NC, Guio-Mahecha E, Quintero-Lesmes DC, et al.Lipid profile, plasma apolipoproteins, and pre-eclampsia risk in the GenPE case-control study.Atherosclerosis, 8,6:189-194.
    [10] Bedi Jr KC, Snyder NW, Brandimarto J, et al.Evidence for intramyocardial disruption of lipid metabolism and increased myocardial ketone utilization in advanced human heart failure.Circulation, 6,3(8):706-716.
    [11] Pea JM, Aspberg S, MacFadyen J, et al.Statin therapy and risk of fracture:results from the JUPITER randomized clinical trial.JAMA Intern Med, 5,5(2):171-177.
    [12] Ridker PM, Lonn E, Paynter NP, et al.Primary prevention with statin therapy in the elderly:new Meta-analyses from the contemporary JUPITER and HOPE-3 randomized trials.Circulation, 7,5(20):1979-1981.
    [13] Khera AV, Demler OV, Adelman SJ, et al.Cholesterol efflux capacity, high-density lipoprotein particle number, and incident cardiovascular events:an analysis from the JUPITER trial (justification for the use of statins in prevention:an intervention trial evaluating Rosuvastatin).Circulation, 7,5(25):2494-2504.
    [14] Mach F, Baigent C, Catapano AL, et al.2019 ESC/EAS guidelines for the management of dyslipidaemias:lipid modification to reduce cardiovascular risk.Atherosclerosis, 9,0:140-205.
    [15] Stegman B, Shao M, Nicholls SJ, et al.Coronary atheroma progression rates in men and women following high-intensity statin therapy:a pooled analysis of REVERSAL, ASTEROID and SATURN.Atherosclerosis, 6,4:78-84.
    [16] Prasad M, Sara JD, Widmer RJ, et al.Triglyceride and triglyceride/HDL (high density lipoprotein) ratio predict major adverse cardiovascular outcomes in women with non-obstructive coronary artery disease.J Am Heart Assoc, 9,8(9):e009442.
    [17] Vallée A, Lelong H, Lopez-Sublet M, et al.Association between different lipid parameters and aortic stiffness:clinical and therapeutic implication perspectives.J Hypertens, 9,7(11):2240-2246.
    [18] Ronsein GE, Hutchins PM, Isquith D, et al.Niacin therapy increases high-density lipoprotein particles and total cholesterol efflux capacity but not ABCA1-specific cholesterol efflux in statin-treated subjects.Arterioscler Thromb Vasc Biol, 6,6(2):404-411.
    [19] Chandra A, Neeland IJ, Das SR, et al.Relation of black race between high density lipoprotein cholesterol content, high density lipoprotein particles and coronary events (from the Dallas Heart Study).Am J Cardiol, 5,5(7):890-894.
    [20] 徐瑞霞, 郭远林, 张彦, 等.多廿烷醇联合阿托伐他汀治疗对高脂血症患者高密度脂蛋白颗粒的影响.中国动脉硬化杂志, 7,5(2):149-152.
    [21] 万进东, 王丹, 刘森, 等.血浆致动脉硬化指数对早发急性冠状动脉综合征患者PCI术后预后的影响.中国动脉硬化杂志, 8,6(7):705-710.
    [22] 李超, 白明, 彭瑜, 等.非高密度脂蛋白胆固醇与冠状动脉病变严重程度的相关性.中国动脉硬化杂志, 9,7(4):344-348.
    Related
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

WAN Jindong, RAN Fei, XIA Siwei, YANG Lun, CHEN Shichao, WANG Dan, LIU Sen, YANG Yi, ZHOU Peng, WANG Peijian. Association between high density lipoprotein particle size and silent myocardial ischemia in young patients with coronary heart disease[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2020,28(12):1054-1059.

Copy
Share
Article Metrics
  • Abstract:710
  • PDF: 718
  • HTML: 0
  • Cited by: 0
History
  • Received:December 08,2019
  • Revised:February 11,2020
  • Online: December 14,2020
Article QR Code

You are the 57367 visitor

Post Code：421001 Fax：0734-8160523

Phone：0734-8160765 E-mail：dmzzbjb@163.net

Editorial Office of Chinese Journal of Arteriosclerosis ® 2025