2025年6月12日 周四
Home > Archive>Volume 28, Issue 11, 2020 >997-1001
PDF HTML XML Export Cite reminder
Research progress on anti-aging of mesenchymal stem cell
Author:
Affiliation:

Department of Cardiology, Xiangya Second Hospital, Central South University, Changsha, Hunan 410011, China)

Clc Number:

R5

  • Article
    • | |
  • Metrics
    • |
  • Reference [47]
    • | | | |
  • Comments
    Abstract:

    With the aging of population, the burden of medical is aggravated. As a new treatment method, stem cell transplantation has reversed aging and its accompanying dysfunction. Mesenchymal stem cell, as a type of stem cell with both regeneration and immunoregulatory functions, can promote the regeneration and repair of aging tissues through direct differentiation of cell replacement and cell empowerment. At the same time, recent studies have found that continuous centrifugation can separate exosomes which is the main therapeutic carrier from mesenchymal stem cell. Senescence-related miRNA in exosomes is helpful to elucidate the molecular mechanism of anti-aging treatment of mesenchymal stem cell.

    Reference
    [1] Hayflick L, Moorhead PS.The serial cultivation of human diploid cell strains.Exp Cell Res, 1,5:585-621.
    [2] Lopez-Otin C, Blasco MA, Partridge L, et al.The hallmarks of aging.Cell, 3,3(6):1194-1217.
    [3] Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al.Embryonic stem cell lines derived from human blastocysts.Science, 8,2(5391):1145-1147.
    [4] Sharpless NE, DePinho RA.How stem cells age and why this makes us grow old.Nat Rev Mol Cell Biol, 7,8(9):703-713.
    [5] Dominici M, Le Blanc K, Mueller I, et al.Minimal criteria for defining multipotent mesenchymal stromal cells:The international society for cellular therapy position statement.Cytotherapy, 6,8(4):315-317.
    [6] Koliakos G.Stem cells and aging.Rejuvenation Res, 7,0(1):4-8.
    [7] Rose RA, Jiang H, Wang X, et al.Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro.Stem Cells, 8,6(11):2884-2892.
    [8] Hare JM, Traverse JH, Henry TD, et al.A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction.J Am Coll Cardiol, 9,4(24):2277-2286.
    [9] Florea V, Rieger AC, DiFede DL, et al.Dose comparison study of allogeneic mesenchymal stem cells in patients with ischemic cardiomyopathy (the TRIDENT study).Circ Res, 7,1(11):1279-1290.
    [10] Wu H, Li JZ, Xie BD, et al.Lower senescence of adipose-derived stem cells than donor-matched bone marrow stem cells for surgical ventricular restoration.Stem Cells Dev, 8,7(9):612-623.
    [11] Park D, Yang G, Bae DK, et al.Human adipose tissue-derived mesenchymal stem cells improve cognitive function and physical activity in ageing mice.J Neurosci Res, 3,1(5):660-670.
    [12] Cao N, Liao T, Liu J, et al.Clinical-grade human umbilical cord-derived mesenchymal stem cells reverse cognitive aging via improving synaptic plasticity and endogenous neurogenesis.Cell Death Dis, 7,8(8):e2996.
    [13] Charles-de-Sa L, Gontijo-de-Amorim NF, Maeda Takiya C, et al.Antiaging treatment of the facial skin by fat graft and adipose-derived stem cells.Plast Reconstr Surg, 5,5(4):999-1009.
    [14] Dong L, Hao H, Xia L, et al.Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth.Sci Rep, 4,4:5432.
    [15] Huang S, Feng C, Wu Y, et al.Dissimilar characteristics of umbilical cord mesenchymal stem cells from donors of different ages.Cell Tissue Bank, 3,4(4):707-713.
    [16] Zhou L, Chen X, Liu T, et al.Melatonin reverses H2O2-induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway.J Pineal Res, 5,9(2):190-205.
    [17] Prockop DJ, Kota DJ, Bazhanov N, et al.Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs).J Cell Mol Med, 0,4(9):2190-2199.
    [18] Von Bahr L, Batsis I, Moll G, et al.Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation.Stem Cells, 2,0(7):1575-1578.
    [19] Haynesworth SE, Baber MA, Caplan AI.Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro:effects of dexamethasone and IL-1 alpha.J Cell Physiol, 6,6(3):585-592.
    [20] Kourembanas S.Exosomes:vehicles of intercellular signaling, biomarkers, and vectors of cell therapy.Annu Rev Physiol, 5,7:13-27.
    [21] Kinnaird T, Stabile E, Burnett MS, et al.Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms.Circ Res, 4,4(5):678-685.
    [22] Henning RJ, Dennis S, Sawmiller D, et al.Human umbilical cord blood mononuclear cells activate the survival protein Akt in cardiac myocytes and endothelial cells that limits apoptosis and necrosis during hypoxia.Transl Res, 2,9(6):497-506.
    [23] Gnecchi M, He H, Liang OD, et al.Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.Nat Med, 5,1(4):367-368.
    [24] Mirotsou M, Zhang Z, Deb A, et al.Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair.Proc Natl Acad Sci USA, 7,4(5):1643-1648.
    [25] Timmers L, Lim SK, Arslan F, et al.Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium.Stem Cell Res, 7,1(2):129-137.
    [26] Henning RJ, Burgos JD, Ondrovic L, et al.Human umbilical cord blood progenitor cells are attracted to infarcted myocardium and significantly reduce myocardial infarction size.Cell Transplant, 6,5(7):647-658.
    [27] Henning RJ, Shariff M, Eadula U, et al.Human cord blood mononuclear cells decrease cytokines and inflammatory cells in acute myocardial infarction.Stem Cells Dev, 8,7(6):1207-1219.
    [28] Rajendran RL, Gangadaran P, Bak SS, et al.Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice.Sci Rep, 7,7(1):15560.
    [29] Mitsialis SA, Kourembanas S.Stem cell-based therapies for the newborn lung and brain:Possibilities and challenges.Semin Perinatol, 6,0(3):138-151.
    [30] Rashed MH, Bayraktar E, Helal GK, et al.Exosomes:from garbage bins to promising therapeutic targets.Int J Mol Sci, 7,8(3):538.
    [31] Willis GR, Kourembanas S, Mitsialis SA.Therapeutic applications of extracellular vesicles:perspectives from newborn medicine.Methods Mol Biol, 7,0:409-432.
    [32] Kowal J, Arras G, Colombo M, et al.Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes.Proc Natl Acad Sci USA, 6,3(8):E968-E977.
    [33] Lai RC, Arslan F, Lee MM, et al.Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.Stem Cell Res, 0,4(3):214-222.
    [34] Arslan F, Lai RC, Smeets MB, et al.Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury.Stem Cell Res, 3,0(3):301-312.
    [35] Reis LA, Borges FT, Simoes MJ, et al.Bone marrow-derived mesenchymal stem cells repaired but did not prevent gentamicin-induced acute kidney injury through paracrine effects in rats.PLoS One, 2,7(9):e44092.
    [36] Hisamatsu D, Ohno-Oishi M, Nakamura S, et al.Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues.Aging, 6,8(6):1259-1275.
    [37] Du WW, Yang W, Fang L, et al.miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7.Cell Death Dis, 4,5:e1355.
    [38] Gombar S, Jung HJ, Dong F, et al.Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing.BMC Genomics, 2,3:353.
    [39] Yu JM, Wu X, Gimble JM, et al.Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow.Aging cell, 1,0(1):66-79.
    [40] Boehm M, Slack F.A developmental timing microRNA and its target regulate life span in C.elegans.Science, 5,0(5756):1954-1957.
    [41] Liu L, Wang Y, Fan H, et al.MicroRNA-181a regulates local immune balance by inhibiting proliferation and immunosuppressive properties of mesenchymal stem cells.Stem Cells, 2,0(8):1756-1770.
    [42] Davis C, Dukes A, Drewry M, et al.MicroRNA-183-5p increases with age in bone-derived extracellular vesicles, suppresses bone marrow stromal (stem) cell proliferation, and induces stem cell senescence.Tissue Eng Part A, 7,3(21-22):1231-1240.
    [43] Lalu MM, McIntyre L, Pugliese C, et al.Safety of cell therapy with mesenchymal stromal cells (safe cell):a systematic review and meta-analysis of clinical trials.PLoS One, 2,7(10):e47559.
    [44] Lee AS, Tang C, Rao MS, et al.Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies.Nat Med, 3,9(8):998-1004.
    [45] Peterson SE, Garitaonandia I, Loring JF.The tumorigenic potential of pluripotent stem cells:what can we do to minimize it?.Bioessays, 6,8(Suppl 1):S86-S95.
    [46] King NM, Perrin J.Ethical issues in stem cell research and therapy.Stem Cell Res Ther, 4,5(4):85.
    [47] Yoshihara M, Hayashizaki Y, Murakawa Y.Genomic instability of iPSCs:challenges towards their clinical applications.Stem Cell Rev Rep, 7,3(1):7-16.
    Related
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

LI Yixi, LIU Qiming, LIU Na, WU Keke. Research progress on anti-aging of mesenchymal stem cell[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2020,28(11):997-1001.

Copy
Share
Article Metrics
  • Abstract:996
  • PDF: 1510
  • HTML: 0
  • Cited by: 0
History
  • Received:October 14,2019
  • Revised:November 28,2019
  • Online: November 30,2020
Article QR Code

You are the 57942 visitor

Post Code：421001 Fax：0734-8160523

Phone：0734-8160765 E-mail：dmzzbjb@163.net

Editorial Office of Chinese Journal of Arteriosclerosis ® 2025