Research progress of non-coding RNA in vascular calcification
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Department of Cardiology, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518033, China)

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R543

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    Abstract:

    Vascular calcification (VC) increases the incidence of cardiovascular events in patients with chronic kidney disease, hypertension and diabetes mellitus. However, up to now, the molecular mechanism leading to VC has not been fully elucidated, and there is a lack of effective treatment methods, so it is necessary to find new therapeutic targets.With the development of molecular biological analysis technology, non-coding RNA has become an important research hotspot. It has been reported that non-coding RNA can regulate the expressions of osteogenic gene or osteogenic inhibition gene, or regulate autophagy and aging process to regulate VC under the stimulation of VC promoting factors. This review mainly summarizes the research progress of non-coding RNA (microRNA, long non-coding RNA and circular RNA) in VC.

    Reference
    [1] Wu M, Rementer C.Giachelli CM.Vascular calcification:an update on mechanisms and challenges in treatment.Calcif Tissue Int, 3,3(4):365-373.
    [2] Djebali S, Davis CA, Merkel A, et al.Landscape of transcription in human cells.Nature, 2,9(7414):101-108.
    [3] Fernandes JCR, Acuna SM, Aoki JI, et al.Long non-coding RNAs in the regulation of gene expression:physiology and disease.Noncoding RNA, 9,5(1):17.
    [4] Lin X, Xu F, Cui RR, et al.Arterial calcification is regulated via an miR-204/DNMT3a regulatory circuit both in vitro and in female mice.Endocrinology, 8,9(8):2905-2916.
    [5] Chang Z, Yan G, Zheng J, et al.The lncRNA GAS5 inhibits the osteogenic differentiation and calcification of human vascular smooth muscle cells.Calcif Tissue Int, 0,7(1):86-95.
    [6] Chao CT, Liu YP, Su SF, et al.Circulating microRNA-125b predicts the presence and progression of uremic vascular calcification.Arterioscler Thromb Vasc Biol, 7,7(7):1402-1414.
    [7] Doherty TM, Asotra K, Fitzpatrick LA, et al.Calcification in atherosclerosis:bone biology and chronic inflammation at the arterial crossroads.Proc Natl Acad Sci USA, 3,0(20):11201-11206.
    [8] Leopold JA.Vascular calcification:Mechanisms of vascular smooth muscle cell calcification.Trends Cardiovasc Med, 5,5(4):267-274.
    [9] Paloian NJ, Giachelli CM.A current understanding of vascular calcification in CKD.Am J Physiol Renal Physiol, 4,7(8):F891-F900.
    [10] Cozzolino M, Ciceri P, Galassi A, et al.The key role of phosphate on vascular calcification.Toxins (Basel), 9,1(4):213.
    [11] Zhang C, Zhang K, Huang F, et al.Exosomes, the message transporters in vascular calcification.J Cell Mol Med, 8,2(9):4024-4033.
    [12] Makeyev EV, Maniatis T.Multilevel regulation of gene expression by microRNAs.Science, 8,9(5871):1789-1790.
    [13] Bartel DP.MicroRNAs:genomics, biogenesis, mechanism, and function.Cell, 4,6(2):281-297.
    [14] Jiang W, Zhang Z, Yang H, et al.The involvement of miR-29b-3p in arterial calcification by targeting matrix metalloproteinase-2.Biomed Res Int, 7,7:6713606.
    [15] Panizo S, Naves-Diaz M, Carrillo-Lopez N, et al.MicroRNAs 29b, 133b, and 211 regulate vascular smooth muscle calcification mediated by high phosphorus.J Am Soc Nephrol, 6,7(3):824-834.
    [16] Zhang H, Chen J, Shen Z, et al.Indoxyl sulfate accelerates vascular smooth muscle cell calcification via microRNA-29b dependent regulation of Wnt/beta-catenin signaling.Toxicol Lett, 8,4:29-36.
    [17] Wen P, Cao H, Fang L, et al.miR-125b/Ets1 axis regulates transdifferentiation and calcification of vascular smooth muscle cells in a high-phosphate environment.Exp Cell Res, 4,2(2):302-312.
    [18] Chao CT, Yuan TH, Yeh HY, et al.Risk factors associated with altered circulating micro RNA-125b and their influences on uremic vascular calcification among patients with end-stage renal disease.J Am Heart Assoc, 9,8(2):e010805.
    [19] Badi I, Mancinelli L, Polizzotto A, et al.miR-34a promotes vascular smooth muscle cell calcification by downregulating SIRT1 (sirtuin 1) and Axl (AXL receptor tyrosine kinase).Arterioscler Thromb Vasc Biol, 8,8(9):2079-2090.
    [20] Hao J, Zhang L, Cong G, et al.MicroRNA-34b/c inhibits aldosterone-induced vascular smooth muscle cell calcification via a SATB2/Runx2 pathway.Cell Tissue Res, 6,6(3):733-746.
    [21] Xu F, Zhong JY, Lin X, et al.Melatonin alleviates vascular calcification and ageing through exosomal miR-204/miR-211 cluster in a paracrine manner.J Pineal Res, 0,8(3):e12631.
    [22] Wang C, Xu W, An J, et al.Poly (ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2.Nat Commun, 9,0(1):1203.
    [23] Cavallari C, Dellepiane S, Fonsato V, et al.Online hemodiafiltration inhibits inflammation-related endothelial dysfunction and vascular calcification of uremic patients modulating miR-223 expression in plasma extracellular vesicles.J Immunol, 9,2(8):2372-2383.
    [24] Balderman JA, Lee HY, Mahoney CE, et al.Bone morphogenetic protein-2 decreases microRNA-30b and microRNA-30c to promote vascular smooth muscle cell calcification.J Am Heart Assoc, 2,1(6):e003905.
    [25] Xu TH, Qiu XB, Sheng ZT, et al.Restoration of microRNA-30b expression alleviates vascular calcification through the mTOR signaling pathway and autophagy.J Cell Physiol, 9,4(8):14306-14318.
    [26] Knauss JL, Sun T.Regulatory mechanisms of long noncoding RNAs in vertebrate central nervous system development and function.Neuroscience, 3,5:200-214.
    [27] Yao RW, Wang Y, Chen LL.Cellular functions of long noncoding RNAs.Nat Cell Biol, 9,1(5):542-551.
    [28] Ransohoff JD, Wei Y, Khavari PA.The functions and unique features of long intergenic non-coding RNA.Nat Rev Mol Cell Biol, 8,9(3):143-157.
    [29] Wang KC, Chang HY.Molecular mechanisms of long noncoding RNAs.Mol Cell, 1,3(6):904-914.
    [30] Bao S, Guo Y, Diao Z, et al.Genome-wide identification of lncRNAs and mRNAs differentially expressed in human vascular smooth muscle cells stimulated by high phosphorus.Ren Fail, 0,2(1):437-446.
    [31] Jeong G, Kwon DH, Shin S, et al.Long noncoding RNAs in vascular smooth muscle cells regulate vascular calcification.Sci Rep, 9,9(1):5848.
    [32] Gao W, Zhu M, Wang H, et al.Association of polymorphisms in long non-coding RNA H19 with coronary artery disease risk in a Chinese population.Mutat Res, 5,2:15-22.
    [33] Liu F, Yang XC, Chen ML, et al.LncRNA H19/Runx2 axis promotes VSMCs transition via MAPK pathway.Am J Transl Res, 0,2(4):1338-1347.
    [34] Lin X, Zhan JK, Zhong JY, et al.lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs.Aging (Albany NY), 9,1(2):523-535.
    [35] Zhang X, Chen J, Meng Q, et al.The protective effects of long non-coding RNA-ANCR on arterial calcification.J Bone Miner Metab, 0,8(4):421-431.
    [36] Memczak S, Jens M, Elefsinioti A, et al.Circular RNAs are a large class of animal RNAs with regulatory potency.Nature, 3,5(7441):333-338.
    [37] Li M, Ding W, Sun T, et al.Biogenesis of circular RNAs and their roles in cardiovascular development and pathology.FEBS J, 8,5(2):220-232.
    [38] Zhang Z, Yang T, Xiao J.Circular RNAs:promising biomarkers for human diseases.EBioMedicine, 8,4:267-274.
    [39] Ryu J, Kwon DH, Choe N, et al.Characterization of circular RNAs in vascular smooth muscle cells with vascular calcification.Mol Ther Nucleic Acids, 0,9:31-41.
    [40] Mo MH, Chen L, Fu Y, et al.Cell-free circulating miRNA biomarkers in cancer.J Cancer, 2,3:432-448.
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WU Qimin, ZHANG Xinxia. Research progress of non-coding RNA in vascular calcification[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2020,28(11):955-959, 971.

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  • Received:May 29,2020
  • Revised:July 26,2020
  • Online: November 30,2020
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