The relationship between ACE/ACE2, RAS inhibitors and COVID-19 from the mechanism
Author:
Affiliation:

1.Department of Cardiology, the First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan 423000, China;2.Department of Hypertension, Beijing Anzhen Hospital of Capital Medical University, Beijing 100029, China)

Clc Number:

R5

  • Article
  • | |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • | |
  • Comments
    Abstract:

    Since the discovery and spread of coronavirus disease 2019 (COVID-19), it has aroused widespread concern from all walks of life. There are different opinions on the relationship among angiotension converting enzyme (ACE)/ACE2, renin-angiotension system (RAS) inhibitors and COVID-19 in medical circles. ACE and ACE2 are similar in structure but have opposite effects. The positive ACE-AngⅡ-AT1R axis and the negative ACE2-Ang(1-7)-Mas axis in vivo check and balance each other to maintain the stability of blood pressure and internal environment. A number of basic studies have shown that different RAS inhibitors have inconsistent effects on ACE2. The causal relationship between ACE2 and COVID-19 has not been clarified, and no clinical evidence has been found that the use of RAS inhibitors aggravates COVID-19. The consideration of ACE2 influencing COVID-19 is basically derived from the theoretical derivation of RAS and the inference of the basic research results of SARS. Whether cardiovascular disease patients with COVID-19 use RAS inhibitors should be combined with clinical practice and weighing the pros and cons. Evidence-based RAS inhibitors cannot be arbitrarily discontinued in the current ambiguous situation.

    Reference
    Related
    Cited by
Get Citation

TANG Xinying, KUANG Zemin. The relationship between ACE/ACE2, RAS inhibitors and COVID-19 from the mechanism[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2020,28(5):390-394, 399.

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:March 09,2020
  • Revised:March 25,2020
  • Online: May 26,2020
Article QR Code