Patients with corona virus disease 2019 (COVID-19) presented typical respiratory symptoms, as well as a certain degree of cardiac injury. COVID-19 patients with cardiovascular diseases are prone to deterioration and high mortality. Coronary heart disease, as the most common cardiovascular disease in the middle-aged and the elderly, widely exists in severe COVID-19 patients, which has a serious impact on the course of disease. This article will discuss the influence of severe COVID-19 on the drug treatment of coronary heart disease, to optimize the treatment strategy and improve the prognosis of patients.