Effects of Xuezhikang on low-density lipoprotein subfractions and oxidized LDL in patients with hyperlipidemia

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Effects of Xuezhikang on low-density lipoprotein subfractions and oxidized LDL in patients with hyperlipidemia
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                        ZHANG YueZHANG Yue
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease ＆ Fu Wai Hospital ＆ National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
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XU RuixiaXU Ruixia
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease ＆ Fu Wai Hospital ＆ National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
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ZHANG YanZHANG Yan
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease ＆ Fu Wai Hospital ＆ National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
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WU YaruWU Yaru
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease ＆ Fu Wai Hospital ＆ National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
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LI JianjunLI Jianjun
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease ＆ Fu Wai Hospital ＆ National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
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Affiliation:Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease ＆ Fu Wai Hospital ＆ National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China)
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Abstract:

Aim To investigate the effects of Xuezhikang (XZK) on low-density lipoprotein (LDL) subfractions and oxidized low-density lipoprotein (ox-LDL) in patients with hyperlipidemia. Methods A total of 40 subjects (20 patients with hyperlipidemia and 20 healthy subjects) who were not treated with lipid-lowering drugs were selected consecutively and divided into the XZK group (n=20) and the control group (n=20). The plasma LDL subfractions, ox-LDL were examined by using the Lipoprint system at baseline and again after 8 weeks. Results Data showed that XZK could significantly decrease not only plasma LDLC levels, total cholesterol, triglycerides, and apolipoprotein B (P＜0.05), but also ox-LDL (P＜0.05). At the same time, XZK reduced the concentration of small LDLC (P＜0.05) and the percentage of the small LDL subfraction (P＜0.05). Conclusion XZK treatment for 8 weeks significantly improved the blood lipid profile, reduced the concentration and percentage of atherogenic small LDLC, and reduced the level of oxidative stress.

Key words:Xuezhikang; hyperlipidemia; low-density lipoprotein subfraction; oxidized LDL

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ZHANG Yue, XU Ruixia, ZHANG Yan, WU Yaru, LI Jianjun. Effects of Xuezhikang on low-density lipoprotein subfractions and oxidized LDL in patients with hyperlipidemia[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2020,28(3):229-232.

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Received:June 03,2019
Revised:August 09,2019
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Online: January 20,2020
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