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Role of rapamycin in delaying re-endothelialization after angioplasty
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1.Department of Cardiology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China;2.Department of Cardiology, the Seventh Medical Center of Chinese PLA General Hospital, Beijing 100700, China)

Clc Number:

R5

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    Abstract:

    Rapamycin is the most widely employed drug in drug-eluting stents. It has markedly reduced the risk of restenosis after coronary angioplasty. However, it caused late stent thrombosis through impairing the function of endothelial cells and delaying the re-endothelialization. Role of rapamycin in delaying re-endothelialization is complicated. This paper reviews the progress in research of the mechanism of suppressing the proliferation and migration of endothelial cells, attenuating the function of endothelial progenitor cells and inducing apoptosis of endothelial cells.

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WANG Wei, ZHANG Yingqian, LI Zhongxuan, CHEN Yundai. Role of rapamycin in delaying re-endothelialization after angioplasty[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2019,27(11):995-999.

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History
  • Received:November 28,2018
  • Revised:March 06,2019
  • Online: December 18,2019
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