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The relationship between neutrophil gelatinase-associated lipocalin and cardiovascular diseases
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Department of Cardioelectrophysiology, the Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, China)

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R5

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    Abstract:

    Neutrophil gelatinase-associated lipocalin (NGAL), also known as Lcn2 (lipocalin 2), or oncogene 24p3, is a gelatinase complex stored in mature neutrophil-specific particles. Glycoproteins are also produced by other cell types, including cardiomyocytes. NGAL is an early biomarker of acute kidney injury. Recently, NGAL has been found to be an independent predictor of major adverse cardiovascular events and mortality, but the relationship between NGAL and cardiovascular disease (CVD) has not been agreed. This article reviews the relationship between NGAL and coronary heart disease, hypertension and heart failure, and the targeted therapy of NGAL and CVD.

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ZHANG Ying, LIU Xiaoteng, JIN Fengbiao, LIU Qiumei, LIU Huiqing, GAO Yu, HOU Ruitian. The relationship between neutrophil gelatinase-associated lipocalin and cardiovascular diseases[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2019,27(10):915-920.

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History
  • Received:December 04,2018
  • Revised:February 21,2019
  • Online: September 19,2019
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