Aim To study the relationship between apolipoprotein E gene polymorphism and coronary heart disease in women. Methods Apolipoprotein E, female coronary heart disease, and gene polymorphism were used as the search terms, and Wanfang, CNKI, Chinese biomedical literature, SpringerLink database and PubMed database were searched from foundation September 0,8. Alleles E2 and E4 were compared with E3, and genotypes E2/2, E2/3, E2/4, E3/4 and E4/4 were compared with E3/3, respectively. Statistical software Stata14.0 was used for Meta analysis of all data, and combined odds ratio (OR value) and 95% confidence interval (95%CI) were used to describe the counting data. The heterogeneity analysis process was completed with I², and it was considered that there was significant heterogeneity when P<0.1 or I²>50%. Publication bias was analyzed using funnel plot. The reliability of the results was assessed by sensitivity analysis. P<0.05 was considered statistically significant. Results A total of 940 related literatures were retrieved, and 9 literatures were finally included. One in Chinese and eight in English. The selected literatures were all case-control studies, and the literatures were evaluated by NOS quality score scale. The selected literatures were all higher than 5 points, which was considered as high-quality literatures. Meta analysis results of selected literature showed that genotype E2/2(OR 4.5,5%CI (1.2,1.19)), E3/4(OR 1.8,5%CI (1.0,2.82)), E4/4(OR 4.5,5%CI (2.6,9.60)) were significantly higher in the case group than in the control group, E2/3(OR 1.0,5%CI (0.9,1.54)), E2/4(OR 1.3,5%CI (0.1,2.07)) had no statistical significance in the incidence of female coronary heart disease. Conclusion The risk of coronary heart disease increased significantly in women with the genotype E2/2, E3/4 and E4/4.