The impact of obesity on atherosclerosis

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The impact of obesity on atherosclerosis
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                        SUN HengSUN Heng
Department of Endocrinology and Metabolism, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China
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QI XiaoyanQI Xiaoyan
Department of Endocrinology and Metabolism, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China
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XIAO XinhuaXIAO Xinhua
Department of Endocrinology and Metabolism, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China
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Affiliation:Department of Endocrinology and Metabolism, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China)
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Abstract:

Obesity is a chronic metabolic disease caused by a variety of factors, manifested by excessive accumulation of body fat and/or abnormal fat distribution. The main pathogenesis of atherosclerosis is lipid accumulation within the artery walls, the proliferation of smooth muscle cell and fibrous matrix, and development of atherosclerosis plaques. A large number of basic and clinical studies have shown that obesity is a well-established risk factor for atherosclerosis, and its potential mechanisms include abnormal lipid metabolism, insulin resistance, inflammation, and endothelial dysfunction.However, the mechanistic link between accumulation of adipose tissue and development of atherosclerosis is not clear. This article will focus on the opinions of epicardial adipose tissue and perivascular adipose tissue, new adipokines, adipose-derived exosomes, and adipose browning, in order to state the impact of obesity on atherosclerosis and to provide a new perspective for the study of intervention strategies for atherosclerosis.

Key words:obesity; ectopic fat depots; exosome; adipose browning; atherosclerosis

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SUN Heng, QI Xiaoyan, XIAO Xinhua. The impact of obesity on atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2019,27(10):829-834.

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Received:June 10,2019
Revised:September 02,2019
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Online: September 19,2019
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