Insulin-like growth factor 1 and heart failure

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Insulin-like growth factor 1 and heart failure
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                        YU XingYU Xing
Department of Cardiology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, China
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ZHENG JianyiZHENG Jianyi
Department of Cardiology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, China
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CAI TengfeiCAI Tengfei
Department of Cardiology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, China
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ZHU GuipingZHU Guiping
Department of Cardiology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, China
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Affiliation:Department of Cardiology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, China)
Clc Number:R541.6
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Abstract:

Insulin-like growth factor 1(IGF-1)is an important cytokine whose structure and function are significantly similar to insulin. It has been shown to exist in most tissues and belongs to the insulin family. It plays an important physiological function by binding to its own specific receptor. With the deepening of research on the relationship between IGF-1 and cardiovascular diseases, IGF-1 has been found to promote myocardial growth, enhance myocardial contractility, and inhibit apoptosis, which are closely related to the development of heart failure(HF).

Key words:insulin-like growth factor 1; heart failure; insulin-like growth factor 1 receptor

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YU Xing, ZHENG Jianyi, CAI Tengfei, ZHU Guiping. Insulin-like growth factor 1 and heart failure[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2019,27(9):819-822.

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Received:January 29,2019
Revised:April 15,2019
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Online: July 08,2019
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