Research progress of visceral adipose tissue and myocardial fibrosis
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Department of Cardiology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China)

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R541

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    Abstract:

    Obesity is closely related to myocardial fibrosis, especially the correlation between visceral adipose tissue and myocardial fibrosis, which has attracted the attention of the medical community. A number of studies have confirmed that visceral adipose tissue participates in myocardial fibrosis by secreting a variety of adipocytokines such as leptin and adiponectin, and its mechanism of action is complicated. Recent studies have shown that visceral adipose tissue can also promote myocardial fibrosis by producing osteopontin. The emerging bioelectrical impedance analysis method for measuring visceral adipose tissue will also lay the foundation for further clinical application and research. This article reviews the involvement of visceral adipose tissue in the production of myocardial fibrosis and its determination method.

    Reference
    [1] Gao YJ.Dual modulation of vascular function by perivascular adipose tissue and its potential correlation with adiposity/lipoatrophy-related vascular dysfunction.Curr Pharm Des, 7,3(21):2185-2192.
    [2] Fuster JJ, Ouchi N, Gokce N, et al.Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease.Circ Res, 6,8(11):1786-1807.
    [3] Le Jemtel TH, Samson R, Milligan G, et al.Visceral adipose tissue accumulation and residual cardiovascular risk.Curr Hypertens Rep, 8,0(9):77.
    [4] Cavalera M, Wang J, Frangogiannis NG.Obesity, metabolic dysfunction, and cardiac fibrosis:pathophysiological pathways, molecular mechanisms, and therapeutic opportunities.Transl Res, 4,4(4):323-335.
    [5] Wang CY, Li SJ, Wu TW, et al.The role of pericardial adipose tissue in the heart of obese minipigs.Eur J Clin Invest, 8,8(7):e12942.
    [6] Yang R, Chang L, Liu S, et al.High glucose induces Rho/ROCK-dependent visfatin and type I procollagen expression in rat primary cardiac fibroblasts.Mol Med Rep, 4,0(4):1992-1998.
    [7] Zibadi S, Cordova F, Slack EH, et al.Leptin's regulation of obesity-induced cardiac extracellular matrix remodeling.Cardiovasc Toxicol, 1,1(4):325-333.
    [8] Martinez-Martinez E, Jurado-Lopez R, Valero-Munoz M, et al.Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress:potential role in obesity.J Hypertens, 4,2(5):1104-1114.
    [9] Samuel CS, Unemori EN, Mookerjee I, et al.Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo.Endocrinology, 4,5(9):4125-4133.
    [10] Young MJ.Mechanisms of mineralocorticoid receptor-mediated cardiac fibrosis and vascular inflammation.Curr Opin Nephrol Hypertens, 8,7(2):174-180.
    [11] Huby AC, Antonova G, Groenendyk J, et al.Adipocyte-derived hormone leptin is a direct regulator of aldosterone secretion, which promotes endothelial dysfunction and cardiac fibrosis.Circulation, 5,2(22):2134-2145.
    [12] Packer M.Leptin-aldosterone-neprilysin axis:identification of its distinctive role in the pathogenesis of the three phenotypes of heart failure in people with obesity.Circulation, 8,7(15):1614-1631.
    [13] Fukui A, Takahashi N, Nakada C, et al.Role of leptin signaling in the pathogenesis of angiotensin Ⅱ-mediated atrial fibrosis and fibrillation.Circ Arrhythm Electrophysiol, 3,6(2):402-409.
    [14] Wang Q, Xi W, Yin L, et al.Human epicardial adipose tissue ctgf expression is an independent risk factor for atrial fibrillation and highly associated with atrial fibrosis.Sci Rep, 8,8(1):3585.
    [15] Ryo M, Nakamura T, Kihara S, et al.Adiponectin as a biomarker of the metabolic syndrome.Circ J, 4,8(11):975-981.
    [16] Ouchi N, Kihara S, Funahashi T, et al.Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue.Circulation, 3,7(5):671-674.
    [17] Engeli S, Feldpausch M, Gorzelniak K, et al.Association between adiponectin and mediators of inflammation in obese women.Diabetes, 3,2(4):942-947.
    [18] Barbarash O, Gruzdeva O, Uchasova E, et al.The role of adipose tissue and adipokines in the manifestation of type 2 diabetes in the long-term period following myocardial infarction.Diabetol Metab Syndr, 6,8:24.
    [19] Gruzdeva O, Uchasova E, Dyleva Y, et al.Relationships between epicardial adipose tissue thickness and adipo-fibrokine indicator profiles post-myocardial infarction.Cardiovasc Diabetol, 8,7(1):40.
    [20] Kawarazaki W, Fujita T.The role of aldosterone in obesity-related hypertension.Am J Hypertens, 6,9(4):415-423.
    [21] 尚冬升, 边云飞, 杨慧宇, 等.脂联素在高血压致炎症和心肌纤维化中的作用.中国动脉硬化杂志, 5,3(05):464-468.
    [22] Yan CJ, Li SM, Xiao Q, et al.Influence of serum adiponectin level and SNP +45 polymorphism of adiponectin gene on myocardial fibrosis.J Zhejiang Univ Sci B, 3,4(8):721-728.
    [23] Qi GM, Jia LX, Li YL, et al.Adiponectin suppresses angiotensin II-induced inflammation and cardiac fibrosis through activation of macrophage autophagy.Endocrinology, 4,5(6):2254-2265.
    [24] Essick EE, Ouchi N, Wilson RM, et al.Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling.Am J Physiol Heart Circ Physiol, 1,1(3):H984-H993.
    [25] Dadson K, Chasiotis H, Wannaiampikul S, et al.Adiponectin mediated APPL1-AMPK signaling induces cell migration, MMP activation, and collagen remodeling in cardiac fibroblasts.J Cell Biochem, 4,5(4):785-793.
    [26] Guo BY, Li YJ, Han R, et al.Telmisartan attenuates isoproterenol-induced cardiac remodeling in rats via regulation of cardiac adiponectin expression.Acta Pharmacol Sin, 1,2(4):449-455.
    [27] Xia Y, Zhang F, Zhao S, et al.Adiponectin determines farnesoid X receptor agonism-mediated cardioprotection against post-infarction remodelling and dysfunction.Cardiovasc Res, 8,4(10):1335-1349.
    [28] Chemaly ER, Hadri L, Zhang S, et al.Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats.J Mol Cell Cardiol, 1,1(2):144-155.
    [29] Hernandez-Romero D, Orenes-Pinero E, Garcia-Honrubia A, et al.Involvement of the -420C>G RETN polymorphism in myocardial fibrosis in patients with hypertrophic cardiomyopathy.J Intern Med, 5,8(1):50-58.
    [30] Costa S, Reina-Couto M, Albino-Teixeira A, et al.Statins and oxidative stress in chronic heart failure.Rev Port Cardiol, 6,5(1):41-57.
    [31] Dai DF, Johnson SC, Villarin JJ, et al.Mitochondrial oxidative stress mediates angiotensin Ⅱ-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure.Circ Res, 1,8(7):837-846.
    [32] Cucoranu I, Clempus R, Dikalova A, et al.NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts.Circ Res, 5,7(9):900-907.
    [33] Westermann D, Van Linthout S, Dhayat S, et al.Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy.Basic Res Cardiol, 7,2(6):500-507.
    [34] Fukuhara A, Matsuda M, Nishizawa M, et al.Visfatin:a protein secreted by visceral fat that mimics the effects of insulin.Science, 5,7(5708):426-430.
    [35] Yu XY, Qiao SB, Guan HS, et al.Effects of visfatin on proliferation and collagen synthesis in rat cardiac fibroblasts.Horm Metab Res, 0,2(7):507-513.
    [36] Cardin S, Scott-Boyer MP, Praktiknjo S, et al.Differences in cell-type-specific responses to angiotensin Ⅱ explain cardiac remodeling differences in C57BL/6 mouse substrains.Hypertension, 4,4(5):1040-1046.
    [37] Ndisang JF, Chibbar R, Lane N.Heme oxygenase suppresses markers of heart failure and ameliorates cardiomyopathy in L-NAME-induced hypertension.Eur J Pharmacol, 4,4:23-34.
    [38] Zhao H, Wang W, Zhang J, et al.Inhibition of osteopontin reduce the cardiac myofibrosis in dilated cardiomyopathy via focal adhesion kinase mediated signaling pathway.Am J Transl Res, 6,8(9):3645-3655.
    [39] Sawaki D, Czibik G, Pini M, et al.Visceral adipose tissue drives cardiac aging through modulation of fibroblast senescence by osteopontin production.Circulation, 8,8(8):809-822.
    [40] Lee DH, Park KS, Ahn S, et al.Comparison of abdominal visceral adipose tissue area measured by computed tomography with that estimated by bioelectrical impedance analysis method in korean subjects.Nutrients, 5,7(12):10513-10524.
    [41] Finch P.Intra-abdominal fat:Comparison of computed tomography fat segmentation and bioimpedance spectroscopy.Malawi Med J, 7,9(2):155-159.
    [42] Eickemberg M, Oliveira CC, Roriz AK, et al.Bioelectrical impedance and visceral fat:a comparison with computed tomography in adults and elderly.Arq Bras Endocrinol Metabol, 3,7(1):27-32.
    [43] Nagai M, Komiya H, Mori Y, et al.Development of a new method for estimating visceral fat area with multi-frequency bioelectrical impedance.Tohoku J Exp Med, 8,4(2):105-112.
    [44] Park KS, Lee DH, Lee J, et al.Comparison between two methods of bioelectrical impedance analyses for accuracy in measuring abdominal visceral fat area.J Diabetes Complications, 6,0(2):343-349.
    [45] Yang SW, Kim TH, Choi HM.The reproducibility and validity verification for body composition measuring devices using bioelectrical impedance analysis in Korean adults.J Exerc Rehabil, 8,4(4):621-627.
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WU Jinxu, ZHANG Mingyu, ZHOU Tao. Research progress of visceral adipose tissue and myocardial fibrosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2019,27(9):808-812.

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History
  • Received:November 06,2018
  • Revised:January 23,2019
  • Online: July 08,2019
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