Aim To observe the relationship between plasma glycine level and coronary SYNTAX scores in patients with stable angina pectoris (SAP). Methods Using case-control study design, 120 patients with SAP were assigned to SAP group and 120 age-matched and gender-matched physical examinees were assigned to control group. Coronary angiography was performed in SAP group. According to SYNTAX scores (SS), SAP group was divided into low SS group, middle SS group and high SS group. The clinical data of SAP group and control group were compared. The clinical data of SAP subgroup and control group were compared by variance analysis. The influencing factors of SAP and the relationship between plasma glycine and SYNTAX scores were analyzed by logistic regression. Results High density lipoprotein cholesterol (HDLC) in SAP group was significantly lower than that in control group (P<0.05), low density lipoprotein cholesterol (LDLC), high sensitivity C-reactive protein (hs-CRP) and plasma glycine were significantly higher than those in control group (P<0.05). There were significant differences in HDLC, LDLC, hs-CRP and glycine levels between SAP subgroup and control group (P<0.05). Logistic regression analysis showed that the prevalence of SAP increased with the increase of plasma glycine, LDLC and SYNTAX scores, and plasma glycine (OR=1.6,5%CI:1.013～1.246, P<0.01) was an independent predictor of moderate and high SYNTAX scores. Conclusion The plasma glycine, LDLC and SYNTAX scores were the influencing factors of SAP, and plasma glycine was the independent predictor of high and medium SYNTAX scores.