Inflammatory caspase regulate the innate immunity and its implication in cardiovascular diseases

Home > Archive>Volume 27, Issue 6, 2019 >536-541

Inflammatory caspase regulate the innate immunity and its implication in cardiovascular diseases
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                        PAN Bingjie1,2PAN Bingjie
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China;Center for Vascular Disease and Translational Medicine, the Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China
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TIAN Xiaoting1TIAN Xiaoting
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China
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LI Xiaohui1,3LI Xiaohui
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China;Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha, Hunan 411000, China
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Affiliation:1.Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China;2.Center for Vascular Disease and Translational Medicine, the Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China;3.Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha, Hunan 411000, China)
Clc Number:R962；R5
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Abstract:

More and more studies have revealed that inflammation plays an important role in cardiovascular diseases, including hypertension and atherosclerosis et al. Caspase-1, caspase-4, caspase-5 and caspase-11 are named as inflammatory caspase, which cause the mature and secretion of inflammatory cytokines. Inflammatory caspase can induce and magnify inflammatory response that represents a new paradigm in innate immunity. In addition to mediating cleavage of the NLRP3 inflammasome-associated cytokines interleukin 1beta (IL-1β) and IL-18, inflammatory caspase modulate distinct forms of pyroptosis by shearing gasdermin D into N-terminal fragment that showed pore-forming activity, while pyroptosis of cells release a large number of inflammatory cytokines. This study will discuss the role of inflammatory caspase in cardiovascular diseases.

Key words:caspase; innate immunity; inflammation; cardiovascular diseases

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PAN Bingjie, TIAN Xiaoting, LI Xiaohui. Inflammatory caspase regulate the innate immunity and its implication in cardiovascular diseases[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2019,27(6):536-541.

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Received:October 06,2018
Revised:November 21,2018
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Online: June 04,2019
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