Aim To study the Influence of albumin in vulnerable phase among ejection fraction retention heart failure and ejection fraction intermediate heart failure(HFpEF and HFmrEF)patients. Methods Continuously selected 151 patients which diagnosed in heart failure in China Medical University (including 85 HFpEF patients and 66 HFmrEF patients). 151 patients with non-heart failure were enrolled in the same period. The patient's clinical data were collected and followed up. Clinical outcomes were defined as all cause mortality and rehospitalization due to worsening HF. Compared baseline data between the two groups, and used univariate logistic regression analysis to determine risk factors for patients with heart failure. Evaluated influence of albumin in vulnerable phase through Cox regression analysis and Kaplan-Meier survival analysis. Results The albumin of HFpEF and HFmrEF patients was obviously higher than non-heart failure patients(t=－6.431,P<0.001). Logistic regression analysis OR 0.162(95%CI 0.098~0.268, P<0.001). Albumin may be the protective factor of HFpEF and HFmrEF. Cox regression analysis and Kaplan-Meier survival analysis showed that serum albumin was associated with vulnerable phase prognosis in patients with HFpEF and HFmrEF. Univariate COX analysis (HR=0.1,5%CI 0.188~0.655, P=0.001) and multivariate COX analysis (HR=0.9,5%CI 0.225~0.858, P=0.016) were significant. Kaplan-Meier analysis between higher albumin group and lower albumin group(log-rank:χ²=11.881,P=0.001)also showed significant difference. Conclusions Serum albumin may be a risk factor for patients with HFpEF and HFmrEF. The lower the serum albumin, the worse the prognosis of the vulnerable period.