New progress in research on low shear stress and atherosclerosis

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New progress in research on low shear stress and atherosclerosis
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                        TAN Lilan1TAN Lilan
Key Laboratory for Arteriosclerology of Hunan Province & Institute of Cardiovascular Disease, University of South China, Hengyang, Hunan 421001, China
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LUO Yong2LUO Yong
Intensive Care Unit of the Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China
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XIAO Chen1XIAO Chen
Key Laboratory for Arteriosclerology of Hunan Province & Institute of Cardiovascular Disease, University of South China, Hengyang, Hunan 421001, China
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ZHANG Shaoze1ZHANG Shaoze
Key Laboratory for Arteriosclerology of Hunan Province & Institute of Cardiovascular Disease, University of South China, Hengyang, Hunan 421001, China
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WEI Dangheng1WEI Dangheng
Key Laboratory for Arteriosclerology of Hunan Province & Institute of Cardiovascular Disease, University of South China, Hengyang, Hunan 421001, China
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WANG Chunyan1WANG Chunyan
Key Laboratory for Arteriosclerology of Hunan Province & Institute of Cardiovascular Disease, University of South China, Hengyang, Hunan 421001, China
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Affiliation:1.Key Laboratory for Arteriosclerology of Hunan Province & Institute of Cardiovascular Disease, University of South China, Hengyang, Hunan 421001, China;2.Intensive Care Unit of the Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China)
Clc Number:R363；R54
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Abstract:

The process of atherosclerotic lesions is a proliferative response induced by arterial intimal injury, which occurs in the bifurcation and branching regions of the arteries with low shear stress (LSS). LSS regulates gene expression and phenotype transformation by activating membrane receptors and intracellular signal transduction on cells, and plays an important role in the occurrence and development of atherosclerosis. This article reviews the relationship between LSS and endothelial cell inflammation, endothelial-to-mesenchymal transition, endothelial cell autophagy and its regulatory mechanism, hoping to provide new ideas and strategies for the prevention and treatment of atherosclerosis.

Key words:low shear stress; atherosclerosis; endothelial-to-mesenchymal transition; autophagy

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TAN Lilan, LUO Yong, XIAO Chen, ZHANG Shaoze, WEI Dangheng, WANG Chunyan. New progress in research on low shear stress and atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2019,27(5):432-438.

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Received:September 27,2018
Revised:October 31,2018
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Online: April 08,2019
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