Research progress of anti-atherosclerotic drugs targeting liver X receptors

Home > Archive>Volume 27, Issue 3, 2019 >254-263

Research progress of anti-atherosclerotic drugs targeting liver X receptors
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                        FU Yu1FU Yu
College of Bioscience and Bioengineering, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018, China
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LI Ni2,3LI Ni
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China;National Center for Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China
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Affiliation:1.College of Bioscience and Bioengineering, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018, China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China;3. National Center for Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China)
Clc Number:R363；R5
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Abstract:

Liver X receptors (LXRs) are nuclear factors and play important roles in the regulation of cholesterol homeostasis in the body. LXRs regulate cholesterol metabolism in different tissues through regulating their target genes. LXR agonists can promote the reverse cholesterol transport in order to inhibit atherosclerosis, and have potential therapeutic effects on cardiovascular diseases. In this paper, the new LXR agonists in recent years are reviewed for their anti-atherosclerotic effects from different sources, characteristics and mechanisms.

Key words:liver X receptors; agonist; atherosclerosis; cholesterol metabolism

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FU Yu, LI Ni. Research progress of anti-atherosclerotic drugs targeting liver X receptors[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2019,27(3):254-263.

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Received:October 10,2018
Revised:November 21,2018
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Online: January 28,2019
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