Roles of lipoprotein lipase in triglyceride metabolism and atherosclerosis

Home > Archive>Volume 27, Issue 1, 2019 >81-86

Roles of lipoprotein lipase in triglyceride metabolism and atherosclerosis
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                        XIONG Fang1,2XIONG Fang
Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Human Province, Medical Research Center,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study;School of Pharmacy, University of South China, Hengyang, Hunan 421001, China
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WANG Zongbao1,2WANG Zongbao
Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Human Province, Medical Research Center,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study;School of Pharmacy, University of South China, Hengyang, Hunan 421001, China
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TANG Chaoke1TANG Chaoke
Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Human Province, Medical Research Center,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study
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Affiliation:1. Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Human Province, Medical Research Center,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study;2. School of Pharmacy, University of South China, Hengyang, Hunan 421001, China)
Clc Number:R363；R5
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Abstract:

Triglyceride (TG) is predominantly present in triglyceride-rich lipoproteins (TRLs). Dysregulation of TRL metabolism is closely associated with the occurrence and development of atherosclerosis. Lipoprotein lipase (LPL), a glycoprotein secreted by parenchyma cells, can cleave TG within the TRLs to produce free fatty acid. A variety of factors are involved in TRL metabolism and atherosclerosis progression by regulating LPL expression and activity. Thus, clarifying the role TRL metabolism and its regulatory mechanisms could have significant implications for the prevention and treatment of cardiovascular disease.

Key words:triglyceride; triglyceride rich lipoproteins; lipoprotein lipase; atherosclerosis

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XIONG Fang, WANG Zongbao, TANG Chaoke. Roles of lipoprotein lipase in triglyceride metabolism and atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2019,27(1):81-86.

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Received:July 02,2018
Revised:December 24,2018
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Online: January 21,2019
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