Research progress of the relationship between ApoCⅢ and atherosclerosis cardiovascular diseases

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Research progress of the relationship between ApoCⅢ and atherosclerosis cardiovascular diseases
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                        CHEN Ruirui1CHEN Ruirui
Shanxi Medical University, Taiyuan, Shanxi 030000, China
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ZHOU Hua2ZHOU Hua
Department of Cardiology, the Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030000, China
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Affiliation:1.Shanxi Medical University, Taiyuan, Shanxi 030000, China;2.Department of Cardiology, the Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030000, China)
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Abstract:

Apolipoprotein CⅢ (ApoCⅢ) not only participates in the occurrence and development of atherosclerosis cardiovascular diseases(ASCVD) through lipid metabolism disorders, but also has been recognized as an independent factor of inflammatory and atherosclerosis. Clinical studies have found that ApoCⅢ was linked with cardiovascular disease(CVD), and its cellular effects related with CVD are also confirmed in basic research. Fortunately, in addition to traditional therapeutic strategies, such as lifestyle changes and lipid-lowering drug treatments, antisense oligonucleotides specifically targeting ApoCⅢ mRNA have opened the door to a new era of reducing ApoCⅢ and the treatment of CVD. Therefore, this paper summarizes the clinical significance of ApoCⅢ and the future treatment direction.

Key words:apolipoprotein CⅢ; atherosclerosis; gene therapy

Reference

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CHEN Ruirui, ZHOU Hua. Research progress of the relationship between ApoCⅢ and atherosclerosis cardiovascular diseases[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(12):1291-1296.

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Received:March 19,2018
Revised:May 12,2018
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Online: December 27,2018
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