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microRNA regulates autophagy and its role in atherosclerosis
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Institute of Cardiovascular Disease ＆ Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China)

Clc Number:

R34

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    Abstract:

    Atherosclerosis (As) is the main pathological factor of cardiovascular and cerebrovascular diseases. The pathological mechanism of the development of atherosclerosis has not been fully elucidated so far. Autophagy is a highly biological process in eukaryotic cells. Normal levels of autophagy inhibit the development of atherosclerosis, and autophagy defects or excessive autophagy accelerate plaque rupture, which lead to the occurrence of cerebrovascular accidents. Studies have shown that microRNA affects As processes by participating in the regulation of autophagy in As-related cells. This article reviews the role of microRNA in the regulation of autophagy levels in endothelial cells, macrophages, and smooth muscle cells in As.

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LIU Yami, ZENG Zhaolin, CHEN Jiaojiao, TAO Jun, WANG Zuo. microRNA regulates autophagy and its role in atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(12):1278-1284.

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History
  • Received:February 27,2018
  • Revised:December 02,2018
  • Online: December 27,2018
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