Vascular calcification is an active biological process similar to bone and cartilage formation with multiple regulatory factors involved in. At present, the main clinical treatment strategy for vascular calcification is still limited to mechanical therapy. However, with the progress of research, there have been more and more attempts and explorations for targeted interventions for vascular calcification, including chemical drugs such as phosphate binders, pyrophosphates and bisphosphonates, thiosulfates and targeted intervention in OPG/RANK/RANKL signaling, osteoclasts, etc. However, these intervention strategies have different degrees of defects and development bottlenecks. How to effectively dissolve and absorb hydroxyapatite crystals and amorphous calcium deposits, reverse the progression of vascular wall calcification phenotype and return to normal, and fully take into account the bi-directional balance of bone-vessel axis, is still tough work ahead and a long way to go.