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Scavenger receptor BI and atherosclerosis
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School of Basic Medical Sciences, Wuhan University & Hubei Key Laboratory of Developmental Diseases, Wuhan, Hubei 430071, China)

Clc Number:

R363

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    Abstract:

    Scavenger receptor type B class I (SR-BI) is the first glycoprotein defined as a high density lipoprotein (HDL) receptor on the cell membrane, which mediates the selective uptake of high density lipoprotein cholesterol (HDL) by cells, affecting cell cholesterol balance and inflammatory status. Liver SR-BI plays an important role in reverse cholesterol transport, and is closely related to HDL metabolism and its role in anti-atherogenesis. It has been found that humans have SR-BI gene polymorphisms. This review focuses on SR-BI structure, function, regulation and its role on atherosclerosis.

    Reference
    [1] Acton S, Rigotti A, Landschulz KT, et al.Identification of scavenger receptor SR-BI as a high density lipoprotein receptor.Science, 6,1(5248):518-520.
    [2] Linton MF, Tao H, Linton EF, et al.SR-BI:Amultifunctional receptor in cholesterol homeostasis and atherosclerosis.Trends Endocrinol Metab, 7,8(6):461-472.
    [3] Vergeer M, Korporaal SJ, Franssen R, et al.Genetic variant of the scavenger receptor BI in humans.N Engl J Med, 1,4(2):136-145.
    [4] Zanoni P, Khetarpal SA, Larach DB, et al.Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.Science, 6,1(6278):1166-1171.
    [5] Vinals M, Xu S, Vasile E, et al.Identification of the N-linked glycosylation sites on the high density lipoprotein (HDL) receptor SR-BI and assessment of their effects on HDL binding and selective lipid uptake.J Biol Chem, 3,8(7):5325-5332.
    [6] Kocher O, Yesilaltay A, Cirovic C, et al.Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism.J Biol Chem, 3,8(52):52820-52825.
    [7] Gaidukov L, Nager AR, Xu S, et al.Glycine dimerization motif in the N-terminal transmembrane domain of the high density lipoprotein receptor SR-BI required for normal receptor oligomerization and lipid transport.J Biol Chem, 1,6(21):18452-18464.
    [8] Holme RL, Miller JJ, Nicholson K, et al.Tryptophan 415is critical for the cholesterol transport functions of scavenger receptor BI.Biochemistry, 6,5(1):103-113.
    [9] Rigotti A, Miettinen HE, Krieger M.The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues.Endocr Rev, 3,4(3):357-387.
    [10] Rigotti A, Trigatti BL, Penman M, et al.A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism.Proc Natl Acad Sci U S A, 7,4(23):12610-12615.
    [11] Dole VS, Matuskova J, Vasile E, et al.Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice.Arterioscler Thromb Vasc Biol, 8,8(6):1111-1116.
    [12] Thacker SG, Rousset X, Esmail S, et al.Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice.J Lipid Res, 5,6(7):1282-1295.
    [13] 尔璐, 边云飞, 宋晓苏, 等.失功能高密度脂蛋白与心血管疾病研究进展.中国动脉硬化杂志, 7,5(3):309-313.
    [14] West M, Greason E, Kolmakova A, et al.Scavenger receptor class B type I protein as an independent predictor of high-density lipoprotein cholesterol levels in subjects with hyperalphalipoproteinemia.J Clin Endocrinol Metab, 9,4(4):1451-1457.
    [15] Manichaikul A, Wang XQ, Musani SK, et al.Association of thelipoprotein receptor SCARB1 common missense variant rs4238001 with incident coronary heart disease.PLoS One, 5,0(5):e0125497.
    [16] Constantineau J, Greason E, West M, et al.A synonymous variant in scavenger receptor, class B, type I gene is associated with lower SR-BI protein expression and function.Atherosclerosis, 0,0(1):177-182.
    [17] Vaisman BL, Vishnyakova TG, Freeman LA, et al.Endothelialexpression of scavenger receptor class B, type I protects against development of atherosclerosis in mice.Biomed Res Int, 5,5:607120.
    [18] Fung KY, Wang C, Nyegaard S, et al.SR-BI mediated transcytosis of HDL in brain microvascular endothelial cells is independent of caveolin, clathrin, and PDZK1.Front Physiol, 7,8:841.
    [19] 唐朝克.以ABCA1为靶点防治动脉粥样硬化.中国动脉硬化杂志, 1,9(11):879-884.
    [20] Ji A, Meyer JM, Cai L, et al.Scavenger receptor SR-BI in macrophage lipid metabolism.Atherosclerosis, 1,7(1):106-112.
    [21] Van Eck M, Hoekstra M, Out R, et al.Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo.J Lipid Res, 8,9(1):136-146.
    [22] Niemsiri V, Wang X, Pirim D, et al.Impact of genetic variants in human scavenger receptor class B type I (SCARB1) on plasma lipid traits.Circ Cardiovasc Genet, 4,7(6):838-847.
    [23] Ren K, Lu YJ, Mo ZC, et al.ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs.J Physiol Biochem, 7,3(2):287-296.
    [24] Guo L, Song Z, Li M, et al.Scavenger receptor BI protects against septic death through its role in modulating inflammatory response.J Biol Chem, 9,4(30):19826-19834.
    [25] Feng H, Guo L, Wang D, et al.Deficiency of scavenger receptor BI leads to impaired lymphocyte homeostasis and autoimmune disorders in mice.Arterioscler Thromb Vasc Biol, 1,1(11):2543-2551.
    [26] Cai L, Wang Z, Meyer JM, et al.Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages.J Lipid Res, 2,3(8):1472-1481.
    [27] Song GJ, Kim SM, Park KH, et al.SR-BI mediates high density lipoprotein (HDL)-induced anti-inflammatory effect in macrophages.Biochem Biophys Res Commun, 5,7(1):112-118.
    [28] Al-Jarallah A, Trigatti BL.A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways.Biochim Biophys Acta, 0,1(12):1239-1248.
    [29] Saddar S, Carriere V, Lee WR, et al.Scavenger receptor class B type I is a plasma membrane cholesterol sensor.Circ Res, 3,2(1):140-151.
    [30] Kimura T, Tomura H, Sato K, et al.Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells .J Biol Chem, 0,5(7):4387-4397.
    [31] Zhang QH, Zu XY, Cao RX, et al.An involvement of SR-B1 mediated PI3K-Akt-eNOS signaling in HDL-induced cyclooxygenase 2 expression and prostacyclin production in endothelial cells.Biochem Biophys Res Commun, 2,0(1):17-23.
    [32] Xu J, Qian J, Xie X, et al.High density lipoprotein cholesterol promotes the proliferation of bone-derived mesenchymal stem cells via binding scavenger receptor-B type I and activation of PI3K/Akt, MAPK/ERK1/2 pathways.Mol Cell Biochem, 2,1(1-2):55-64.
    [33] Tan JT, Prosser HC, Vanags LZ, et al.High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1alpha.FASEB J, 4,8(1):206-217.
    [34] Niemeier A, Kovacs WJ, Strobl W, et al.Atherogenic diet leads to posttranslational down-regulation of murine hepatocyte SR-BI expression.Atherosclerosis, 9,2(1):169-175.
    [35] Leiva A, Verdejo H, Benitez ML, et al.Mechanisms regulating hepatic SR-BI expression and their impact on HDL metabolism.Atherosclerosis, 1,7(2):299-307.
    [36] Yang T, Chen C, Zhang B, et al.Induction of Krüppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type Ⅰ.FEBS J, 0,7(18):3780-3788.
    [37] Li G, Thomas AM, Williams JA, et al.Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding.PLoS One, 2,7(4):e35895.
    [38] Sporstol M, Tapia G, Malerod L, et al.Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I.Biochem Biophys Res Commun, 5,1(4):1533-1541.
    [39] Hu Z, Shen WJ, Kraemer FB, et al.MicroRNAs 125a and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B type I in steroidogenic cells.Mol Cell Biol, 2,2(24):5035-5045.
    [40] Wang L, Jia XJ, Jiang HJ, et al.MicroRNAs 5,6, and 223 repress selective high-density lipoprotein cholesterol uptake through posttranscriptional inhibition.Mol Cell Biol, 3,3(10):1956-1964.
    [41] Ren K, Zhu X, Zheng Z, et al.MicroRNA-24 aggravates atherosclerosis by inhibiting selective lipid uptake from HDL cholesterol via the post-transcriptional repression of scavenger receptor class B type I.Atherosclerosis, 8,0:57-67.
    [42] Dai Y, Condorelli G, and Mehta JL.Scavenger receptors and non-coding RNAs:relevance in atherogenesis.Cardiovasc Res, 6,9(1):24-33.
    [43] Hu Z, Hu J, Zhang Z, et al.Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na＋/H＋ exchanger regulatory factors (NHERFs).J Biol Chem, 3,8(16):11416-11435.
    [44] Sticozzi C, Belmonte G, Pecorelli A, et al.Scavenger receptor B1 post-translational modifications in Rett syndrome.FEBS Lett, 3,7(14):2199-2204.
    [45] Huang CX, Zhang YL, Wang JF, et al.MCP-1 impacts RCT by repressing ABCA1, ABCG1, and SR-BI through PI3K/Akt posttranslational regulation in HepG2 cells.J Lipid Res, 3,4(5):1231-1240.
    [46] 李靓, 谢巍, 姜志胜, 等.我国动脉粥样硬化基础研究近三年进展.中国动脉硬化杂志, 5,3(11):1182-1188.
    [47] Hoekstra M.SR-BI as target in atherosclerosis and cardiovascular disease--A comprehensive appraisal of the cellular functions of SR-BI in physiology and disease.Atherosclerosis, 7,8:153-161.
    [48] Cai L, Ji A, de Beer FC, et al.SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance.J Clin Invest, 8,8(1):364-375.
    [49] Nofer JR, van Eck M.HDL scavenger receptor class B type I and platelet function .Curr Opin Lipidol, 1,2(4):277-282.
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DU Fen, YU Hong. Scavenger receptor BI and atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(11):1177-1183.

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History
  • Received:June 15,2018
  • Revised:July 13,2018
  • Online: December 11,2018
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