New research progress on hyperhomocysteinemia and arrhythmia
Author:
Affiliation:

1.The Second Clinical College of Shanxi Medical University, Taiyuan, Shanxi 030001, China;2.Cardiovascular Department, the Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China)

Clc Number:

R54

  • Article
  • | |
  • Metrics
  • |
  • Reference [40]
  • | | | |
  • Comments
    Abstract:

    Homocysteine is a sulfur-containing amino acid needed by human body and an important intermediate metabolite of methionine cycle. In recent years, hyperhomocysteinemia as an independent risk factor of cardiovascular disease has attracted wide attention. At present, more and more evidence shows that hyperhomocysteinemia plays an important role in the occurrence and development of arrhythmia. The purpose of this review is to elucidate the relationship between hyperhomocysteinemia and arrhythmia, and to find new ways to prevent arrhythmia and reduce its mortality.

    Reference
    [1] 苏伟青, 李树裕, 林振, 等.稳心颗粒对冠心病患者血清同型半胱氨酸含量及室性心律失常的影响.山西医药杂志, 3,2(3):314-315.
    [2] 沈娟琴, 屈百鸣.血同型半胱氨酸水平与心电图异常的关系.中国心脏起搏与心电生理杂志, 7,1(1):41-43.
    [3] Yao Y, Yao W, Bai R, et al.Plasma homocysteine levels predict early recurrence after catheter ablation of persistent atrial fibrillation.Europace, 7,9(1):66-71.
    [4] Rosenberger D, Gargoum R, Tyagi N, et al.Homocysteine enriched diet leads to prolonged QT interval and reduced left ventricular performance in telemetric monitored mice.Nutr Metab Cardiovasc Dis, 1,1(7):492-498.
    [5] Li Z, Guo X, Sun G, et al.Plasma homocysteine levels associated with a corrected QT interval.BMC Cardiovasc Disord, 7,7(1):182.
    [6] Zou Z, Lu Y, Dong M, et al.Effect of homocysteine on voltage-gated sodium channel currents in primary cultured rat caudate nucleus neurons and its modulation by 2-arachidonylglycerol.J Mol Neurosci, 5,7(4):477-485.
    [7] 钱红, 蔡本志, 龚冬梅, 等.同型半胱氨酸对豚鼠心房肌细胞钠电流作用的研究.哈尔滨医科大学学报, 7,1(5):411-414.
    [8] Shontz RD, Xu Z, Patel KP, et al.Inhibition of K+ currents by homocysteine in rat ventricular myocytes.J Cardiovasc Electrophysiol, 1,2(2):175-182.
    [9] Chen X, Qin M, Jiang W, et al.Electrophysiological characteristics of pressure overload-induced cardiac hypertrophy and its influence on ventricular arrhythmias.PLoS One, 7,2(9):e0183671.
    [10] Cai B, Gong D, Pan Z, et al.Large-conductance Ca2+-activated K+ currents blocked and impaired by homocysteine in human and rat mesenteric artery smooth muscle cells.Life Sci, 7,0(22):2060-2066.
    [11] Xie W, Santulli G, Guo X, et al.Imaging atrial arrhythmic intracellular calcium in intact heart.J Mol Cell Cardiol, 3,4(4):120-123.
    [12] Maldonado C, Soni CV, Todnem ND, et al.Hyperhomocysteinemia and sudden cardiac death:potential arrhythmogenic mechanisms.Curr Vasc Pharmacol, 0,8(1):64-74.
    [13] 张颖.高同型半胱氨酸血症在脑梗死氧化应激机制中的作用研究.现代诊断与治疗, 7,8(10):1851-1852.
    [14] Hoffman M.Hypothesis:hyperhomocysteinemia is an indicator of oxidant stress.Med Hypotheses, 1,7(6):1088-1093.
    [15] 张芸, 鸿嘎鲁, 席建军.高同型半胱氨酸血症与心血管疾病的相关性研究进展.中国循证心血管医学杂志, 6,8(11):1394-1395.
    [16] Zhang Z, Wei C, Zhou Y, et al.Homocysteine induces apoptosis of human umbilical vein endothelial cells via mitochondrial dysfunction and endoplasmic reticulum stress.Oxid Med Cell Longev, 7,7(1):5736506.
    [17] Wu S, Gao X, Yang S, et al.The role of endoplasmic reticulum stress in endothelial dysfunction induced by homocysteine thiolactone.Fundam Clin Pharmacol, 5,9(3):252-259.
    [18] Xie W, Santulli G, Reiken SR, et al.Mitochondrial oxidative stress promotes atrial fibrillation.Sci Rep, 5,5:11427.
    [19] Joseph LC, Subramanyam P, Radlicz C, et al.Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia.Heart Rhythm, 6,3(8):1699-1706.
    [20] Suematsu N, Ojaimi C, Kinugawa S, et al.Hyperhomocysteinemia alters cardiac substrate metabolism by impairing nitric oxide bioavailability through oxidative stress.Circulation, 7,5(2):255-262.
    [21] 陈静宜, 叶子芯, 崔姝雅, 等.一氧化氮生物利用度失调与动脉粥样硬化.基础医学与临床, 7,7(2):251-255.
    [22] Lai L, Ghebremariam YT.Modulating DDAH/NOS pathway to discover vasoprotective insulin sensitizers.J Diabetes Res, 6,6(2):1982096.
    [23] 曹春辉, 黄军, 陈小亮, 等.内源性硫化氢和同型半胱氨酸与高血压合并主动脉夹层的相关研究.中国循证心血管医学杂志, 6,8(9):1072-1074.
    [24] Ma SF, Luo Y, Ding YJ, et al.Hydrogen sulfide targets the Cys320/Cys529 motif in Kv4.2 to inhibit the Ito potassium channels in cardiomyocytes and regularizes fatal arrhythmia in myocardial infarction.Antioxid Redox Sign, 5,3(2):129-147.
    [25] Kimura Y, Goto Y, Kimura H.Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria.Antioxid Redox Sign, 0,2(1):1-13.
    [26] Pushpakumar S, Kundu S, Sen U.Endothelial dysfunction:the link between homocysteine and hydrogen sulfide.Curr Med Chem, 4,1(32):3662-3672.
    [27] 王会芹, 郭宏, 赵慧.叶酸、维生素B6和维生素B12对高同型半胱氨酸血症大鼠心室重构的影响.中国全科医学, 3,6(3):275-279.
    [28] Naji F, Suran D, Kanic V, et al.High homocysteine levels predict the recurrence of atrial fibrillation after successful electrical cardioversion.Int Heart J, 0,1(1):30-33.
    [29] Yao Y, Shang MS, Dong JZ, et al.Homocysteine in non-valvular atrial fibrillation:Role and clinical implications.Clin Chim Acta, 7,5(9):85-90.
    [30] Moshal KS, Camel CK, Kartha GK, et al.Cardiac dys-synchronization and arrhythmia in hyperhomocysteinemia.Curr Neurovasc Res, 7,4(4):289-294.
    [31] Flevari P, Theodorakis G, Leftheriotis D, et al.Serum markers of deranged myocardial collagen turnover:their relation to malignant ventricular arrhythmias in cardioverter-defibrillator recipients with heart failure.Am Heart J, 2,4(4):530-537.
    [32] Narayanan N, Pushpakumar SB, Givvimani S, et al.Epigenetic regulation of aortic remodeling in hyperhomocysteinemia.FASEB J, 4,8(8):3411-3422.
    [33] Chan CYT, Cheuk BLY, Cheng SWK.Abdominal aortic aneurysm-associated microRNA-516a-5p regulates expressions of methylenetetrahydrofolate reductase, matrix metalloproteinase-2, and tissue inhibitor of matrix metalloproteinase-1 in human abdominal aortic vascular smooth muscle cells.Ann Vasc Surg, 7,2:263-273.
    [34] 臧小彪, 张树龙.缝隙连接蛋白40和心房颤动.心血管病学进展, 1,2(4):554-557.
    [35] Kitamura H, Ohnishi Y, Yoshida A, et al.Heterogeneous loss of connexin 43 protein in nonischemic dilated cardiomyopathy with ventricular tachycardia.J Cardiovasc Electrophysiol, 2,3(9):865-870.
    [36] Rosenberger D, Moshal KS, Kartha GK, et al.Arrhythmia and neuronal/endothelial myocyte uncoupling in hyperhomocysteinemia.Arch Physiol Biochem, 6,2(4-5):219-227.
    [37] 韩璐, 董泉彬, 韦怡春, 等.同型半胱氨酸短期干预对大鼠心房肌细胞钙超载的作用及机制研究.中华心血管病杂志, 8,6(2):143-145.
    [38] Lu Z, Abe J, Taunton J, et al.Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity.Circ Res, 8,3(3):269-278.
    [39] Sun WT, Wang XC, Mak SK, et al.Activation of PERK branch of ER stress mediates homocysteine-induced BKCa channel dysfunction in coronary artery via FoxO3a-dependent regulation of atrogin-1.Oncotarget, 7,8(31):51462-51477.
    [40] Moshal KS, Metreveli N, Frank I, et al.Mitochondrial MMP activation, dysfunction and arrhythmogenesis in hyperhomocysteinemia.Curr Vasc Pharmacol, 8,6(2):84-92.
    Related
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

FENG Gaojie, ZHANG Qinfeng, DAI Pei, GONG Shuwen, GAO Fen. New research progress on hyperhomocysteinemia and arrhythmia[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(10):1070-1074.

Copy
Share
Article Metrics
  • Abstract:857
  • PDF: 975
  • HTML: 0
  • Cited by: 0
History
  • Received:April 19,2018
  • Revised:June 13,2018
  • Online: November 09,2018
Article QR Code