Aim To evaluate the value of soluble suppression of tumorigenicity 2 (sST2) and interleukin 33 (IL-33) in cardiovascular impairment in children with Kawasaki's disease (KD). Methods A total of 282 children with KD admitted to the Department of Pediatrics of Hunan Provincial People's Hospital from December 2013 to January 2017 were selected, including cardiovascular involvement group (n＝35) and cardiovascular uninvolved group (n＝247), and 50 healthy children were as control group. The levels of plasma sST2 and IL-33 were detected in 3 groups of children.Changes and correlations of sST2, IL-33 and conventional inflammatory markers C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and white blood cell count (WBC) were analyzed in KD children with coronary artery lesion. Statistical methods were used to analyze data. Results The levels of plasma sST2 and IL-33 in the cardiovascular involvement group were significantly higher than those in the cardiovascular uninvolved group and the control group (P＜0.05). CRP, ESR and WBC in cardiovascular involvement group and cardiovascular uninvolved group were significantly higher than those in control group (P＜0.05). However, there were no significant differences in CRP, ESR and WBC between the cardiovascular involvement group and the cardiovascular uninvolved group (P＞0.05). After intravenous immunoglobulin therapy, the levels of sST2 and IL-33 were decreased significantly in cardiovascular involvement group (P＜0.05), while the levels of sST2 and IL-33 did not change significantly in cardiovascular uninvolved group (P＞0.05). Pearson correlation analysis showed that the levels of sST2 and IL-33 in KD children were positively correlated with the Z value of echocardiography. Logistic regression analysis showed that sST2 and IL-33 were independent risk factors for cardiovascular injury in KD children (P＜0.05). ROC curve analysis showed that sST2 and IL-33 had high diagnostic value for predicting cardiovascular injury in KD. Conclusions The levels of plasma sST2 and IL-33 are correlated with the degree of cardiovascular injury in children with KD. The analysis of sST2 and IL-33 is helpful to evaluate the degree of cardiovascular injury and predict the prognosis of children with KD.