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Effect of adipose differentiation-related protein on lipid accumulation in foam cell formation
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Institute of Cardiovascular Disease & Key Laboratory for Arteriosclerology of Hunan Province, Hengyang, Hunan 421001, China)

Clc Number:

R363

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    Abstract:

    Atherosclerosis is a common cardiovascular metabolic disease, and its main complications, myocardial infarction and ischemic stroke, have become the first cause of death in the world. The formation of foam cells plays a key role in the development and progression of atherosclerosis. The production of these cells is closely related to intracellular lipid accumulation. Adipose differentiation-related protein (PLIN2) can promote intracellular lipid accumulation. This article mainly discusses the effect of PLIN2 on lipid accumulation in the formation of foam cells, providing new ideas for the prevention and treatment of atherosclerosis.

    Reference
    [1] Chistiakov DA, Melnichenko AA, Myasoedova VA, et al.Mechanisms of foam cell formation in atherosclerosis.J Mol Med, 7,5(11):1153-1165.
    [2] 孙雨萌, 左海奇, 田野.巨噬细胞在血管炎症及动脉粥样硬化中的作用.中国循证心血管医学杂志, 7,9(12):1541-1543.
    [3] Ducharme NA, Bickel PE.Lipid droplets in lipogenesis and lipolysis.Endocrinology, 8,9(3):942-949.
    [4] Conte M, Franceschi C, Sandri M, et al.Perilipin 2 and age-related metabolic diseases:A new perspective.Trends Endocrinol Metab, 6,7(12):893-903.
    [5] Takahashi Y, Shinoda A, Kamada H, et al.Perilipin 2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradation.Sci Rep, 6,6:20975.
    [6] Magne J, Aminoff A, Perman-Sundelin J, et al.The minor allele of the missense polymorphism Ser251Pro in perilipin 2 (PLIN2) disrupts an alpha-helix, affects lipolysis, and is associated with reduced plasma triglyceride concentration in humans.FASEB J, 3,7(8):3090-3099.
    [7] Sentinelli F, Capoccia D, Incani M, et al.The perilipin 2 (PLIN2) gene Ser251Pro missense mutation is associated with reduced insulin secretion and increased insulin sensitivity in Italian obese subjects.Diabetes Metab Res Rev, 6,2(6):550-556.
    [8] Cochain C, Zernecke A.Macrophages in vascular inflammation and atherosclerosis.Pflug Arch Eur J Phy, 7,9(3-4):485-499.
    [9] 王彦方.三酰甘油脂肪酶与动脉粥样硬化的研究进展.中国循证心血管医学杂志, 7,9(7):879-0,4.
    [10] Kaushik S, Cuervo AM.AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA.Autophagy, 6,2(2):432-438.
    [11] Sztalryd C, Brasaemle DL.The perilipin family of lipid droplet proteins:Gatekeepers of intracellular lipolysis.Biochim Biophys Acta, 7,2(10 Pt B):1221-1232.
    [12] Ueno M, Suzuki J, Hirose M, et al.Cardiac overexpression of perilipin 2 induces dynamic steatosis:prevention by hormone-sensitive lipase.Am J Physiol-Endoc M, 7,3(6):E699-E709.
    [13] Feng YZ, Lund J, Li Y, et al.Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation.J Lipid Res, 7,8(11):2147-2161.
    [14] Ghosh S, Zhao B, Bie J, et al.Macrophage cholesteryl ester mobilization and atherosclerosis.Vasc Pharmacol, 0,2(1-2):1-10.
    [15] 孟磊, 谭艳美, 袁中华.中性胆固醇酯水解酶与动脉粥样硬化.中南医学科学杂志, 5,3(2):217-221.
    [16] Larigauderie G, Furman C, Jaye M, et al.Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages:potential role in atherogenesis.Arterioscler Thromb Vasc Biol, 4,4(3):504-510.
    [17] Pourcet B, Staels B.Perilipin2/adipophilin and ApoA-1 team up to combat atherosclerosis.Cardiovasc Res, 6,9(2):193-195.
    [18] Libby AE, Bales E, Orlicky DJ, et al.Perilipin-2 deletion impairs hepatic lipid accumulation by interfering with sterol regulatory element-binding protein (SREBP) activation and altering the hepatic lipidome.J Biol Chem, 6,1(46):24231-24246.
    [19] Forcheron F, Legedz L, Chinetti G, et al.Genes of cholesterol metabolism in human atheroma:overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression.Arterioscler Thromb Vasc Biol, 5,5(8):1711-1717.
    [20] Collot-Teixeira S, Barbatis C, Bultelle F, et al.CD36 is significantly correlated with adipophilin in human carotid lesions and inversely correlated with plasma ApoA1.J Biomed Biotechnol, 8,8(1):813236.
    [21] de Villiers WJ, Smart EJ.Macrophage scavenger receptors and foam cell formation.J Leukocyte Biol, 9,6(5):740-746.
    [22] Liu Q, Dai Z, Liu Z, et al.Oxidized low-density lipoprotein activates adipophilin through ERK1/2 signal pathway in RAW264.7 cells.Acta Bioch Bioph Sin, 0,2(9):635-645.
    [23] Li J, Mihalcioiu M, Li L, et al.Vitamin D prevents lipid accumulation in murine muscle through regulation of PPAR gamma and perilipin-2 expression.J Steroid Biochem Mol Biol, 7,7:116-124.
    [24] Fazio S, Linton M.Failure of ACAT inhibition to retard atherosclerosis.New Engl J Med, 6,4(12):1307-1309.
    [25] Son SH, Goo YH, Chang BH, et al.Perilipin 2 (PLIN2)-deficiency does not increase cholesterol-induced toxicity in macrophages.PLoS One, 2,7(3):e33063.
    [26] 乔运城, 彭娟, 刘志强, 等.巨噬细胞荷脂过程中脂肪分化相关蛋白与酰基辅酶A胆固醇酰基转移酶.中国动脉硬化杂志, 4,2(12):1201-1206.
    [27] 袁中华, 贾薇, 黄谙非, 等.脂肪分化相关蛋白通过酰基辅酶A胆固醇酰基转移酶1促进巨噬细胞脂质蓄积.中国动脉硬化杂志, 8,6(2):101-106.
    [28] Qiao Y, Guo D, Meng L, et al.Oxidized-low density lipoprotein accumulates cholesterol esters via the PKC alpha-adipophilin-ACAT1 pathway in RAW264.7 cells.Mol Med Rep, 5,2(3):3599-3606.
    [29] Feingold KR, Kazemi MR, Magra AL, et al.ADRP/ADFP and Mal1 expression are increased in macrophages treated with TLR agonists.Atherosclerosis, 0,9(1):81-88.
    [30] Tan Y, Zhang H, Guo D, et al.Adipophilin involved in lipopolysaccharide-induced inflammation in RAW264.7 cell via extracellular signal-regulated kinase 1/2-peroxisome proliferator-activated receptor gamma pathway.DNA Cell Biol, 7,6(12):1159-1167.
    [31] Angelovich TA, Hearps AC, Jaworowski A.Inflammation-induced foam cell formation in chronic inflammatory disease.Immunol Cell Biol, 5,3(8):683-693.
    [32] Lei L, Xiong Y, Chen J, et al.TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation.J Lipid Res, 9,0(6):1057-1067.
    [33] 高小花, 王庸晋.酰基辅酶A胆固醇酰基转移酶-1与动脉粥样硬化.心血管病学进展, 1,2(4):604-606.
    [34] Plotkin JD, Elias MG, Dellinger AL, et al.NF-kappa B inhibitors that prevent foam cell formation and atherosclerotic plaque accumulation.Nanomed-Nanotechnol Biol Med, 7,3(6):2037-2048.
    [35] McManaman JL, Bales ES, Orlicky DJ, et al.Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease.J Lipid Res, 3,4(5):1346-1359.
    [36] Najt CP, Senthivinayagam S, Aljazi MB, et al.Liver-specific loss of perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis.Am J Physiol Gastrointest Liver Physiol, 6,0(9):G726-G738.
    [37] Chen FL, Yang ZH, Wang XC, et al.Adipophilin affects the expression of TNF-alpha, MCP-1, and IL-6 in THP-1 macrophages.Mol Cell Biochem, 0,7(1-2):193-199.
    [38] Niccoli G, D'Amario D, Borovac JA, et al.Perilipin 2 levels are increased in patients with in-stent neoatherosclerosis:A clue to mechanisms of accelerated plaque formation after drug-eluting stent implantation.Int J Cardiol, 8,8:55-58.
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ZHANG Rui, LI Xiaoge, YUAN Xu, GUO Dongming, YUAN Zhonghua. Effect of adipose differentiation-related protein on lipid accumulation in foam cell formation[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(9):966-972.

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History
  • Received:March 20,2018
  • Revised:May 03,2018
  • Online: October 16,2018
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