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Hepcidin-Fpn1 axis of macrophage iron metabolism and its role in atherosclerosis
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Affiliation:

1.Department of Vascular Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, ;2.Center for Cardiovascular Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China)

Clc Number:

R363

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    Abstract:

    Atherosclerosis (As) is associated with iron metabolism. It is still controversial whether the iron gathered in plaque is a pathogenic factor or a simple consequence caused by hemolysis in the development of As disease. Macrophages play a key role in the formation and development of As plaques. This review summarizes the research progress of macrophage iron metabolism and As. This paper first introduces the Hepcidin-Fpn1 axis that plays an important role in macrophage iron metabolism, and then introduces the effect of macrophage iron metabolism on the development of As from 3 aspects of inflammation, infection and hemorrhage in plaque. Finally, the new ideas of As therapy related to iron metabolism are introduced.

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ZHANG Meng, ZHAO Hongting, CAI Jin, QIAO Tong. Hepcidin-Fpn1 axis of macrophage iron metabolism and its role in atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(9):946-952.

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History
  • Received:September 20,2017
  • Revised:April 11,2018
  • Online: October 16,2018
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