Research progress on the influence of intestinal microbial flora on the immune mechanism of atherosclerosis

Home > Archive>Volume 26, Issue 5, 2018 >531-535

Research progress on the influence of intestinal microbial flora on the immune mechanism of atherosclerosis
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                        JIANG Nan1JIANG Nan
Disease Research Center, Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Traditional Chinese Medicine, Beijing 100700, China
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SUN Hui-Juan1SUN Hui-Juan
Disease Research Center, Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Traditional Chinese Medicine, Beijing 100700, China
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ZHANG Yuan-Yuan2,3ZHANG Yuan-Yuan
Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China;Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China
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MA Ya-Luan1MA Ya-Luan
Disease Research Center, Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Traditional Chinese Medicine, Beijing 100700, China
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Affiliation:1.Disease Research Center, Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Traditional Chinese Medicine, Beijing 100700, China;2.Institute of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China;3.Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China)
Clc Number:R541.4
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Abstract:

Atherosclerosis (As) is closely related to lipid metabolism disorder and inflammation. The current study shows that intestinal microbial flora is also involved in the As process and is one of the independent risk factors of As.The human gut is the largest digestive organ and “the largest immune organ” of the body. Normal intestinal flora participates in bile acid metabolism, and the short-chain fatty acids produced by bacterial metabolism inhibit inflammation, thus suppressing As. Unbalanced intestinal flora affects trimethylamine metabolic pathway of the host, disturbs the metabolism of cholesterol in the body, triggers the innate and adaptive immune responses, and attenuates the protective effect of anti-inflammatory, thus promoting As. Therefore, the regulation of unbalanced intestinal flora becomes a new target for the treatment of As. This article will review the immune mechanism of intestinal flora affecting As.

Key words:Intestinal microbial flora; Inflammatory reaction; Lipid metabolism; Atherosclerosis

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JIANG Nan, SUN Hui-Juan, ZHANG Yuan-Yuan, MA Ya-Luan. Research progress on the influence of intestinal microbial flora on the immune mechanism of atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(5):531-535.

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Received:September 22,2017
Revised:January 17,2018
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Online: May 31,2018
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