The level of serum apolipoprotein CⅢ in patients with acute myocardial infarction and its significance
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The First Affliated Hospital of China Medical University, Shenyang, Liaoning 110000, China)

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R541.4

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    Abstract:

    Aim To observe the level of apolipoprotein CⅢ(ApoCⅢ) in the serum between the patients with acute myocardial infarction and non-coronary heart disease whether they were significantly different, and to explore its clinical significance. Methods A total of 110 patients were enrolled. They were divided into acute myocardial infarction group and non-coronary heart disease group, including 84 people in acute myocardial infarction group, and 26 people in non-coronary heart disease group. The clinical data of patients during hospitalization were collected, including general information such as age, sex, hypertension, diabetes mellitus, dyslipidemia, smoking history, and blood biochemical index data, including serum troponin I(cTnI), triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDLC), uric acid(UA), homocysteine, serum brain natriuretic peptide (BNP), ejection fraction (EF), and serum inflammation index data, including serum cystatin C (CysC) and high-sensitivity C-reactive protein (hs-CRP). The levels of serum apolipoprotein CⅢ in each patient were measured. Results Compared with non-coronary heart disease group (P<0.05), there were more males in the myocardial infarction group, and smoking rate was higher than that of non-coronary heart disease group (P<0.05). Serum cTnI and serum BNP in patients with myocardial infarction were higher than those in non-coronary heart disease group (P<0.05), while HDLC and EF were lower than those of non-coronary heart disease group (P<0.05). The levels of serum CysC, hs-CRP and apolipoprotein CⅢ in the myocardial infarction group were significantly higher than those in the non-coronary heart disease group (P<0.01). Multivariate linear regression analysis showed that there was no significant correlation between apolipoprotein CIII and sex, smoking history, HDLC, cTnI, BNP, EF, CysC, hs-CRP which were significantly different between the two groups. Conclusion The levels of serum apolipoprotein CⅢ in patients with acute myocardial infarction were significantly higher than those in patients without coronary heart disease. Considering that apolipoprotein CⅢ promotes the formation of atherosclerosis by affecting blood lipid metabolism and the process involves a variety of inflammatory mediators, apolipoprotein CⅢ may be a predictor of inflammatory response to acute myocardial infarction.

    Reference
    [1] Norata GD, Tsimikas S, Pirillo A, et al.Apolipoprotein C-Ⅲ:From pathophysiology to pharmacology.Trends Pharmacol Sci, 5,6(10):675-687.
    [2] Proctor SD, Vine DF, Mamo JC.Arterial retention of apolipoprotein B(48)- and B(100)-containing lipoproteins in atherogenesis.Curr Opin Lipidol, 2,3(5):461-470.
    [3] 高润霖.急性心肌梗死诊断和治疗指南.中华心血管病杂志, 1,9(12):9-24.
    [4] 潘柏申.心肌损伤标志物的研究进展与心肌梗死诊断标准的修订.临床检验杂志, 2,0(3):129-132.
    [5] Dichtl W, Nilsson L, Goncalves I, et al.Very low-density lipoprotein activates nuclear factor-kappaB in endothelial cells.Circ Res, 9,4(9):1 085-094.
    [6] Norata GD, Grigore L, Raselli S, et al.Triglyceride-rich lipoproteins from hypertriglyceridemic subjects induce a pro-inflammatory response in the endothelium:molecular mechanisms and gene expression studies.J Mol Cell Cardiol, 6,0(4):484-494.
    [7] Marcoux C, Tremblay M, Fredenrich A, et al.Lipoprotein distribution of apolipoprotein C-Ⅲ and its relationship to the presence in plasma of triglyceride-rich remnant lipoproteins.Metabolism, 1,0(1):112-119.
    [8] Sacks FM.The crucial roles of apolipoproteins E and C-Ⅲ in apoB lipoprotein metabolism in normolipidemia and hypertriglyceridemia.Curr Opin Lipidol, 5,6(1):56-63.
    [9] 刘亚斌, 刘俊.胱抑素C与心血管病相关性的研究进展.心血管病学进展, 0,1(6):864-868.
    [10] Waldeyer C, Karakas M, Scheurle C, et al.The predictive value of different equations for estimation of glomerular filtration rate in patients with coronary artery disease- Results from the AtheroGene study.Int J Cardiol, 6,1:908-913.
    [11] 王金行, 刘青鹏, 刘柏新, 等.急性心肌梗死患者血清胱抑素C和同型半胱氨酸的水平变化.中国老年学杂志, 3,3(7):1 626-628.
    [12] 汪芳, 刘敏.急性心肌梗死患者胱抑素C、白介素-6水平变化及对远期预后的判定意义.临床急诊杂志, 6,7(1):44-47.
    [13] Abid L, Charfeddine S, Kammoun S, et al.Cystatin C:A prognostic marker after myocardial infarction in patients without chronic kidney disease.J Saudi Heart Assoc, 6,8(3):144-151.
    [14] Bi M, Huang Z, Li P, et al.The association between elevated cystatin C levels with myocardial infarction:a meta-analysis.Int J Clin Exp Med, 5,8(11):20 540-547.
    [15] Black S, Kushner I, Samols D.C-reactive Protein.J Biol Chem, 4,9(47):48 487-490.
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WANG Yi-Tong, JIA Zhi-Mei. The level of serum apolipoprotein CⅢ in patients with acute myocardial infarction and its significance[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(5):512-516.

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History
  • Received:September 07,2017
  • Revised:October 14,2017
  • Online: May 31,2018
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