Expression of circulating LIPCAR in patients with chronic heart failure and combined renal insufficiency

Home > Archive>Volume 26, Issue 4, 2018 >384-388

Expression of circulating LIPCAR in patients with chronic heart failure and combined renal insufficiency
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                        WANG Lei1,2WANG Lei
Department of Cardiology,the First Affiliated Hospital of Xinxiang Medical University, ;Heart Center of Xinxiang Medical University, Weihui, Henan 453100, China
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WANG Xue-Hui1,2WANG Xue-Hui
Department of Cardiology,the First Affiliated Hospital of Xinxiang Medical University, ;Heart Center of Xinxiang Medical University, Weihui, Henan 453100, China
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PAN Ya-Ting1,2PAN Ya-Ting
Department of Cardiology,the First Affiliated Hospital of Xinxiang Medical University, ;Heart Center of Xinxiang Medical University, Weihui, Henan 453100, China
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WANG Li-Bo2WANG Li-Bo
Heart Center of Xinxiang Medical University, Weihui, Henan 453100, China
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LIU Hui-Bing2LIU Hui-Bing
Heart Center of Xinxiang Medical University, Weihui, Henan 453100, China
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LV Cheng1,2LV Cheng
Department of Cardiology,the First Affiliated Hospital of Xinxiang Medical University, ;Heart Center of Xinxiang Medical University, Weihui, Henan 453100, China
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LIN Cheng1,2LIN Cheng
Department of Cardiology,the First Affiliated Hospital of Xinxiang Medical University, ;Heart Center of Xinxiang Medical University, Weihui, Henan 453100, China
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ZHANG Min2,3ZHANG Min
Heart Center of Xinxiang Medical University, Weihui, Henan 453100, China;Cardiovascular Division, Kings College London, UK.
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Affiliation:1.Department of Cardiology,the First Affiliated Hospital of Xinxiang Medical University, ;2.Heart Center of Xinxiang Medical University, Weihui, Henan 453100, China;3.Cardiovascular Division, King's College London, UK.)
Clc Number:R446
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Abstract:

Aim To explore the circulating levels of long intergenic non-coding RNA predicting cardiac remodeling (LIPCAR) in patients with chronic heart failure (CHF) and combined renal insufficiency. Methods Venous blood samples were collected from 80 control subjects, 188 patients with CHF, including 80 patients with renal insufficiency, LIPCAR was evaluated by real-time PCR. Results The expression of LIPCAR was significantly different between the control group and the CHF group (1.08±0.28 vs.0.79±0.31, P＜0.01). In addition, the subgroup analysis of CHF showed that the patients complicated with renal insufficiency exhibited a tendency of lower levels of LIPCAR. Furthermore, LIPCAR was negatively correlated with NT-proBNP, whereas positively correlated with ejection fraction (P＜0.01). AUC was 0.777(95%CI＝0.720～0.835) for LIPCAR to judge CHF. Conclusion Circulating LIPCAR levels were significantly downregulated in patients with CHF, especially in those complicated with renal insufficiency. It may be valuable as a potential biomarker for CHF.

Key words:Long intergenic non-coding RNA predicting cardiac remodeling (LIPCAR); Chronic heart failure;Renal insufficiency

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WANG Lei, WANG Xue-Hui, PAN Ya-Ting, WANG Li-Bo, LIU Hui-Bing, LV Cheng, LIN Cheng, ZHANG Min. Expression of circulating LIPCAR in patients with chronic heart failure and combined renal insufficiency[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(4):384-388.

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Received:November 08,2017
Revised:March 13,2018
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Online: May 04,2018
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