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Exercise training attenuates remodeling of CaL channel in cerebral artery of aging hypertensive rats
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Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China)

Clc Number:

R363

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    Abstract:

    Aim To investigate the effects of exercise training on the function of the CaL channels in cerebral arterial smooth muscle cells of aging spontaneously hypertensive rats. Methods 18 3-month-old male Wistar-Kyoto (WKY) rats and 18 spontaneously hypertensive rats (SHR) were used, besides, 16-month-old male WKY and SHR were randomly assigned into either a sedentary group or an exercise-trained group, each group contained 18 rats. The rats in exercise-trained groups ran on a motor treadmill (60 min/d, 5 d/w) at 16~18 m/min for 8 weeks. After 8 weeks training, body weight and heart weight among these groups were measured. The CaL channel function and the expression of CaL channel α1C protein in cerebral artery were measured by whole-cell patch-clamp technique and Western blot. Results(1)Aging effects:Both heart rate and systolic blood pressure in SHR were much higher than those of the same age WKY rats, the systolic blood pressure in 16-month-old rats were significantly higher than the same strain in 3-month-old rats; The CaL channel current density and CaL channel α1C protein expression in young SHR were extremely increased compared with WKY, whereas aging markedly decreased CaL channel current density and CaL channel α1C protein expression in both hypertensive and normotensive rats with no significant differences between them. (2) Exercise effects:The heart weight index (heart weight/ body weight) in aging exercise-trained groups were markedly higher than those in sedentary strains; Exercise training greatly lowered the systolic blood pressure, and increased CaL channel current density and CaL channel α1C protein expression in SHR. Conclusion Aging reduced CaL channel function of cerebral artery from SHR, while exercise training attenuated remodeling of CaL channel.

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CHEN Yu, SHI Li-Jun, WU Ying. Exercise training attenuates remodeling of CaL channel in cerebral artery of aging hypertensive rats[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(4):353-360.

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History
  • Received:September 29,2017
  • Revised:October 25,2017
  • Online: May 04,2018
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